M. Raeschle

The ER-SURF pathway uses ER-mitochondria contact sites for protein targeting to mitochondria

The paper identifies ER-mitochondria contact sites as essential for the ER-SURF pathway's role in transferring mitochondrial precursor proteins from the ER to mitochondria.

MitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol

The paper identifies MitoStores as cytosolic granules that store mitochondrial precursors in yeast, controlled by chaperones Hsp42 and Hsp104 to prevent toxicity.

The metabolite-controlled ubiquitin conjugase Ubc8 promotes mitochondrial protein import by enhancing assembly of the TOM complex

This study shows that Ubc8 promotes mitochondrial protein import by enhancing TOM complex assembly during metabolic transitions in yeast.

Scaling of cellular proteome with ploidy

The paper investigates how gene expression scales with ploidy in budding yeast and identifies a conserved mTORC1-S6K-Tup1 pathway that regulates proteome remodeling.

Nse5/6 inhibits the Smc5/6 ATPase to facilitate DNA substrate selection.

The paper shows Nse5/6 inhibits Smc5/6 ATPase activity, modulating DNA substrate selection in yeast.

The mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

The paper identifies Tom70's role in recruiting cytosolic chaperones to the mitochondrial outer membrane to mitigate proteotoxicity from hydrophobic precursor proteins.

The proteomic inventory reveals the chloroplast ribosome as nexus within a diverse protein network

Affinity purification of Chlamydomonas reinhardtii chloroplast ribosomes and subsequent proteomic analysis revealed a broad spectrum of interactors ranging from global translation control to specific pathways.