Z. Storchova

MitoStores: Chaperone-controlled protein granules store mitochondrial precursors in the cytosol

The paper identifies MitoStores as cytosolic granules that store mitochondrial precursors in yeast, controlled by chaperones Hsp42 and Hsp104 to prevent toxicity.

Genetic instability from a single S-phase after whole genome duplication

This study shows that newly formed tetraploid human cells experience high DNA damage during the first S-phase, leading to abnormal karyotypes and genetic instability.

Scaling of cellular proteome with ploidy

The paper investigates how gene expression scales with ploidy in budding yeast and identifies a conserved mTORC1-S6K-Tup1 pathway that regulates proteome remodeling.

Whole-genome duplication shapes the aneuploidy landscape of human cancers

This study shows that whole-genome duplication (WGD) alters aneuploidy patterns in human cancers, leading to distinct recurrence and genetic interaction patterns between WGD- and WGD+ tumors.

Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies

This study shows that chromosomal instability accelerates cancer cell adaptation to anti-cancer therapies by enabling specific aneuploidy events that reduce drug sensitivity.

USP28 and SPINT2 mediate cell cycle arrest after whole genome doubling

The paper identifies USP28 and SPINT2 as factors that enable tetraploid cell survival by modulating cell cycle arrest and DNA damage responses.

The mitochondrial surface receptor Tom70 protects the cytosol against mitoprotein-induced stress

The paper identifies Tom70's role in recruiting cytosolic chaperones to the mitochondrial outer membrane to mitigate proteotoxicity from hydrophobic precursor proteins.

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint

This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.

Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast

The paper identifies a phosphorylation-regulated interaction between shugoshin and condensin at the centromere in budding yeast, essential for biorientation and chromosome segregation.

The proteomic inventory reveals the chloroplast ribosome as nexus within a diverse protein network

Affinity purification of Chlamydomonas reinhardtii chloroplast ribosomes and subsequent proteomic analysis revealed a broad spectrum of interactors ranging from global translation control to specific pathways.

SUMOylation targets shugoshin to stabilize sister kinetochore biorientation

This study identifies SUMOylation as a mechanism that stabilizes sister kinetochore biorientation by modulating Aurora B kinase and PP2A interactions.

Single chromosome gains can function as metastasis suppressors and metastasis promoters

The paper investigates how single chromosome gains can either suppress or promote metastasis in cancer, showing that specific aneuploidies are linked to distinct clinical outcomes.

Altering microtubule dynamics is synergistically toxic with inhibition of the spindle checkpoint

The paper identifies synergistic toxicity between microtubule dynamics alteration and SAC inhibition in aneuploid cells.