T. Muley

Epigenetic deregulation of IFN and WNT pathways in AT2 cells impairs alveolar regeneration (in COPD)

This study identifies epigenetic changes in AT2 cells from COPD patients that disrupt IFN and WNT pathways, impairing lung regeneration.

Cancer-associated fibroblasts promote drug resistance in ALK-driven lung adenocarcinoma cells by upregulating lipid biosynthesis

This study shows cancer-associated fibroblasts enhance drug resistance in ALK-driven lung adenocarcinoma by promoting lipid biosynthesis and suppressing lipid peroxidation through AKT signaling.

Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in ex-vivo and in vitro models of pulmonary fibrosis

This study shows Dextromethorphan reduces collagen deposition in fibrotic models by inhibiting collagen trafficking in the endoplasmic reticulum.

The pregnancy-associated protein glycodelin as a potential sex-specific target for resistance to immunotherapy in non-small cell lung cancer

This paper identifies glycodelin as a sex-specific factor influencing immunotherapy resistance in NSCLC, showing it impairs survival in female patients and interacts with immune cells.

High-resolution epigenetic profiling identifies novel regulators of COPD in human lung fibroblasts

This study identifies novel epigenetic and transcriptomic regulators of COPD in human lung fibroblasts across disease stages.

Quantitative imaging reveals PI3Kδ inhibition reduces rhinovirus-induced damage of small airway epithelia in ex vivo cultured human precision cut lung slices from COPD patients

Intratumoural heterogeneity and immune modulation in lung adenocarcinoma of female smokers and never smokers

The paper examines intratumoural heterogeneity and immune modulation in lung adenocarcinoma, focusing on female smokers and never smokers, identifying distinct cellular subpopulations and immune interactions.

Versatile workflow for cell type resolved transcriptional and epigenetic profiles from cryopreserved human lung.

This paper develops a cryopreservation workflow for human lung tissue that maintains cell viability and omics profiles, enabling single-cell and bulk sequencing for studying lung diseases.

Multiomic and quantitative label-free microscopy-based analysis of ex vivo culture and TGFbeta1 stimulation of human precision-cut lung slices

The paper uses multiomic and microscopy techniques to study fibrosis in human lung slices, showing increased collagen deposition with TGFbeta1 stimulation and a novel SHG-based method to quantify it.