M. Sadeghi

Sub-membrane actin rings compartmentalize the plasma membrane

This paper shows that sub-membrane actin rings compartmentalize the plasma membrane by confining membrane protein motion in a periodic pattern, observed in neurons and other cell types.

Correspondence between Signaling and Developmental Patterns by Competing Cells: A Computational Perspective

This study presents a computational map showing the correspondence between signaling and developmental patterns in competing cells, enabling prediction of final cell structures and regressive signaling patterns.

Formation of membrane invaginations by curvature-inducing peripheral proteins: free energy profiles, kinetics, and membrane-mediated effects

This study uses steered molecular dynamics and Jarzynski equality to analyze how curvature-inducing peripheral proteins drive membrane invagination, revealing free energy profiles and timescales consistent with experimental observations.

A Compartmentalized Model to Directional Sensing: How can an Amoeboid Cell Unify Pointwise External Signals as an Integrated Entity?

This study presents a compartmentalized model to simulate directional sensing in eukaryotic cells, showing how local signals can be integrated into a preferred orientation.

Protein nanobarcodes enable single-step multiplexed fluorescence imaging

This paper introduces protein nanobarcodes for single-step multiplexed fluorescence imaging, enabling precise analysis of protein combinations.

Investigating the entropic nature of membrane-mediated interactions driving the aggregation of peripheral proteins

This study quantifies membrane-mediated interactions between peripheral proteins, showing entropic forces drive aggregation at low concentrations but energetic effects dominate at high concentrations.

Reactive/Non-cooperative individuals advance Population's Synchronization: Modeling of Dictyostelium discoideum Concerted Signaling during Aggregation Phase

The paper models how reactive and non-cooperative cells in Dictyostelium discoideum influence synchronization and spiral pattern formation during aggregation.

IL-31 uncouples skin inflammation from itch sensation in allergic dermatitis

This study shows IL-31 limits allergic skin inflammation but is essential for itch sensation in dermatitis, uncoupling inflammation from itch.

Thermodynamics and kinetics of aggregation of flexible peripheral membrane proteins

This study develops a coarse-grained model to investigate the thermodynamics and kinetics of protein aggregation on membranes, showing how protein flexibility and surface concentration influence macroscopic aggregation behavior.

Large-scale simulation of biomembranes: bringing realistic kinetics to coarse-grained models

The paper introduces a framework that integrates coarse-grained membrane models with hydrodynamics to simulate biomembranes with realistic kinetics at low computational cost.

A highly divergent picornavirus infecting the gut epithelia of zebrafish (Danio rerio) in research institutions world-wide

The paper identifies a novel picornavirus, ZfPV1, prevalent in zebrafish gut tissue worldwide and describes its genomic and spatial distribution.

Elucidation of the 14-3-3ζ interactome reveals critical roles of RNA splicing factors during adipogenesis

The paper identifies novel adipogenic factors and RNA splicing regulators in the 14-3-3ζ interactome, showing their roles in adipocyte differentiation and alternative splicing.