Author

M. Schlee

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Assay:bulk RNA-seq· 3 Organism:human· 3 Organism:mouse· 2 Assay:ATAC-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

E. Bartok· 5 shared G. Hartmann· 5 shared A. K. de Regt· 2 shared A. Kirchhoff· 2 shared H. Kato· 2 shared K. Ciupka· 2 shared M. Geyer· 2 shared M. Renn· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 32 mutual co-author links

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5 shared papersImmunology

E. Bartok

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Author profile →

5 papers

Recent·Most cited

hnRNPM and ELAVL1 control type I interferon induction by promoting IRF3 phosphorylation downstream of both cGAS and RIG-I

A. Kirchhoff, A.-M. Herzner, C. Urban, A. Piras, R. Düster, J. Wegner, A. Grünewald, T. M. Schlee-Guimaraes, K. Ciupka, P. Leka, R. J. Bootz, A. K. de Regt, B. Kümmerer, M. Honholt Christensen, F. I. Schmidt, , M. Schlee

bioRxiv · Jun 23, 2023 · PreprintImmunology

RIG-I activation primes and trains innate antiviral immune memory

M. S. Adamson, S. Nesic, A. Buness, K. Bayrak, S. Schmitz, S. Soler, T. Zillinger, S. Marx, S. Lambing, K. Andryka-Cegielski, F. Khan, T. M. Schlee-Guimaraes, S. Herberhold, M. Proietti, K. Placek, , E. Bartok

RIG-I activation primes and trains innate immune responses, enhancing non-specific antiviral protection in immune and non-immune cells.

bioRxiv · Oct 27, 2022 · PreprintImmunology

A conserved isoleucine in the binding pocket of RIG-I controls immune tolerance to mitochondrial RNA

A. K. de Regt, K. Anand, K. Ciupka, K. Gatterdam, B. Putschli, D. Fusshoeller, D. Hilbig, A. Kirchhoff, C. Hunkler, S. Wolter, A. Gruenewald, C. Schuberth-Wagner, J. Ludwig, K. Paeschke, E. Bartok, , M. Schlee

This study identifies an isoleucine residue in RIG-I that prevents recognition of 5p-RNA, thereby maintaining immune tolerance to mitochondrial RNA.

bioRxiv · Aug 2, 2022Immunology

RIG-I immunotherapy overcomes radioresistance in p53-positive malignant melanoma

S. Lambing, S. Holdenrieder, P. Müller, Y. P. Tan, C. Hagen, S. Garbe, M. Schlee, J. G. van den Boorn, E. Bartok, G. Hartmann, M. Renn

This study shows that RIG-I ligands enhance radiation-induced tumor cell death and immunogenicity in melanoma, with p53 playing a key role in the synergy between RIG-I and radiation.

bioRxiv · Oct 16, 2021Immunology

RIG-I-induced innate antiviral immunity protects mice from lethal SARS-CoV-2 infection

S. Marx, B. M. Kuemmerer, C. Gruetzner, H. Kato, M. Schlee, E. Bartok, M. Renn, G. Hartmann

This study shows that activating the RIG-I receptor with synthetic RNA oligonucleotides before SARS-CoV-2 infection improves mouse survival and reduces viral load.

bioRxiv · Aug 6, 2021Immunology