Author

S. Welsch

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Cell Biology· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:cryo-EM· 4 Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell signaling & trafficking· 3 Organism:bacteria (other)· 2 Research Focus:cell type annotation· 2 Approach:deep learning· 2 Organism:E. coli· 2

Frequent Co-Authors

G. Hummer· 5 shared B. Turonova· 4 shared M. Beck· 4 shared J. P. Kreysing· 3 shared A. R. Mehdipour· 2 shared D. Wu· 2 shared I. Khusainov· 2 shared S. Safarian· 2 shared

Activity by Year

2019-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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5 shared papersBiophysics

G. Hummer

Mutual co-authors in cluster

Author profile →

9 papers

Recent·Most cited

Passage of the HIV capsid cracks the nuclear pore

J. P. Kreysing, M. Heidari, V. Zila, S. Cruz-Leon, A. Obarska-Kosinska, V. Laketa, S. Welsch, J. Koefinger, B. Turonova, G. Hummer, H.-G. Kraeusslich, M. Beck

This study investigates how HIV-1 capsids pass through nuclear pores, finding that capsids retain their structure and cause NPC scaffold rings to crack.

bioRxiv · Apr 23, 2024Biophysics

Structural and mechanistic insights into human choline and ethanolamine transport

K. Ri, T.-H. Weng, A. Claveras Cabezudo, W. Jösting, Z. Yu, A. Bazzone, N. C. P. Leong, S. Welsch, R. T. Doty, G. Gursu, T. J. Y. Lim, S. L. Schmidt, J. L. Abkowitz, G. Hummer, D. Wu, , S. Safarian

This study identifies FLVCR1 and FLVCR2 as choline and ethanolamine transporters, revealing their structural dynamics and substrate selectivity mechanisms.

bioRxiv · Sep 15, 2023 · PreprintBiophysics

Thinner is not always better: Optimising cryo lamellae for subtomogram averaging

M. W. Tuijtel, J. P. Kreysing, S. Welsch, G. Hummer, M. Beck, B. Turonova

This study benchmarks cryo-ET resolution based on lamella thickness and particle depth, showing no negative impact up to 180 nm and ion-induced damage extending 30 nm from surfaces.

bioRxiv · Jul 31, 2023Biophysics

The killing of human gut commensal E. coli ED1a by tetracycline is associated with severe ribosome dysfunction

I. Khusainov, N. Romanov, C. Goemans, B. Turonova, C. E. Zimmerli, S. Welsch, J. Langer, A. Typas, M. Beck

The paper examines how tetracycline affects ribosome function in two E. coli strains, showing different outcomes based on the antibiotic's bacteriostatic or bactericidal effect.

bioRxiv · Jul 6, 2023Biophysics

Translation dynamics in human cells visualized at high-resolution reveal cancer drug action

H. Xing, R. Taniguchi, I. Khusainov, J. P. Kreysing, S. Welsch, B. Turonova, M. Beck

The paper visualizes ribosome dynamics in human cells at near-atomic resolution, revealing how a cancer drug alters translation.

bioRxiv · Mar 2, 2023Cell Biology

Dissecting the conformational complexity and flipping mechanism of a prokaryotic heme transporter

D. Wu, A. R. Mehdipour, F. Finke, H. G. Goojani, R. R. Groh, T. N. Grund, T. M. Reichhart, R. Zimmermann, S. Welsch, D. Bald, M. Shepherd, G. Hummer, S. Safarian

The paper identifies CydDC as a heme flippase essential for cytochrome bd maturation, revealing its conformational mechanism through cryo-EM and molecular dynamics.

bioRxiv · Apr 7, 2022 · PreprintMicrobiology

Structure-based electron-confurcation mechanism of the Ldh-EtfAB complex

U. Ermler, K. Kayastha, A. Katsyv, C. Himmrichs, S. Welsch, J. M. Schuller, V. Müller

The paper elucidates the structure-based electron-confurcation mechanism of the Ldh-EtfAB complex in Acetobacterium woodii using cryo-EM and AlphaFold2, revealing key redox states and interactions.

bioRxiv · Feb 2, 2022Biochemistry

Cryo-EM structures of pentameric autoinducer-2 exporter from E. coli reveal its transport mechanism

R. Khera, A. R. Mehdipour, J. R. Bolla, J. Kahnt, S. Welsch, U. Ermler, C. Muenke, C. V. Robinson, G. Hummer, H. Xie, H. Michel

The paper reports cryo-EM structures of AI-2 exporters from E. coli, revealing their pentameric structure and elevator-type transport mechanism.

bioRxiv · Oct 20, 2021 · PreprintBiophysics

Multiplexed electron microscopy by fluorescent barcoding allows screening for ultrastructural phenotype

Y. Bykov, N. Cohen, N. Gabrielli, H. Manenschijn, S. Welsch, P. Chlanda, W. Kukulski, K. R. R. Patil, M. Schuldiner, J. A. G. Briggs

The paper introduces a method using fluorescent barcoding and electron microscopy to enable high-throughput screening of ultrastructural phenotypes in yeast.

Journal of Cell Biology · Aug 5, 2019Peer-reviewedCell Biology