Author

J. A. Tainer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Syed· 2 shared A. D. D'Andrea· 1 shared A. D'Souza· 1 shared A. Farkkila· 1 shared A. Li· 1 shared A. Topolska-Wos· 1 shared B. Kochupurakkal· 1 shared B. S. Blagg· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersBiochemistry

A. Syed

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Automating data analysis for hydrogen/deuterium exchange mass spectrometry using data-independent acquisition methodology

F. Filandr, V. Sarpe, S. Raval, D. A. Crowder, M. F. Khan, P. Douglas, S. Coales, R. Viner, A. Syed, J. A. Tainer, S. P. Lees-MIller, D. C. Schriemer

This paper develops an HX-MS2 workflow using DIA methods for automated HX data analysis, improving validation and throughput in proteomics.

Nature Communications · Mar 11, 2024Peer-reviewedBiochemistry

The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the antiviral innate immune response

R. Woltz, B. Schweibenz, S. E. Tsutakawa, C. Zhao, L.-C. Ma, B. Shurina, G. L. Hura, R. John, S. Vorobiev, S. Gurla, M. Solotchi, J. A. Tainer, R. M. Krug, S. S. Patel, G. T. Montelione

bioRxiv · Sep 25, 2023 · PreprintBiochemistry

Two Interaction Surfaces between XPA and RPA Organize the Preincision Complex in Nucleotide Excision Repair

M. Kim, H. S. Kim, A. D'Souza, K. Gallagher, E. Jeong, A. Topolska-Wos, K. Ogorodnik Le Meur, C.-L. Tsai, M.-S. Tsai, M. Kee, J. A. Tainer, J.-E. Yeo, W. J. Chazin, O. D. Scharer

The paper investigates two interaction surfaces between XPA and RPA in the preincision complex of nucleotide excision repair, showing their distinct roles in complex assembly and NER activity.

bioRxiv · Mar 1, 2022Biochemistry

Polymerase Theta Inhibition Kills Homologous Recombination Deficient Tumors

J. Zhou, C. Gelot, C. Pantelidou, A. Li, H. Yucel, R. E. Davis, A. Farkkila, B. Kochupurakkal, A. Syed, G. I. Shapiro, J. A. Tainer, B. S. Blagg, R. Ceccaldi, A. D. D'Andrea

The paper identifies Novobiocin as a POLθ inhibitor that selectively kills HR-deficient tumors, including those resistant to PARP inhibitors.

bioRxiv · May 23, 2020Cancer Biology