Author

M. T. Hoffman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1 Approach:statistical model· 1

Frequent Co-Authors

D. Long· 2 shared H. C. Crawford· 2 shared H.-J. Wen· 2 shared N. G. Steele· 2 shared A. Andren· 1 shared A. L. Myers· 1 shared A. M. Wombwell· 1 shared A. Robinson· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersCancer Biology

D. Long

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Author profile →

2 papers

Recent·Most cited

Tuft cells transdifferentiate to neural-like progenitor cells in the progression of pancreatic cancer

D. J. Salas-Escabillas, M. T. Hoffman, J. S. Moore, S. M. Brender, H.-J. Wen, S. Benitz, E. T. Davis, D. Long, A. M. Wombwell, N. G. Steele, R. C. Sears, I. Matsumoto, K. E. DelGiorno, H. C. Crawford

The paper shows that metaplastic tuft cells in pancreatic cancer transdifferentiate into neural-like progenitor cells, driven by Myc activity, and this transition is linked to poor patient survival.

bioRxiv · Feb 12, 2024Cancer Biology

The Pancreatic Tumor Microenvironment Compensates for Loss of GOT2

S. A. Kerk, L. Lin, A. L. Myers, Y. Zhang, J. A. Jimenez, P. Sajjakulnukit, B. S. Nelson, B. Chen, A. Robinson, G. Thurston, S. B. Kemp, N. G. Steele, M. T. Hoffman, H.-J. Wen, D. Long, , C. A. Lyssiotis

This study shows that the pancreatic tumor microenvironment compensates for loss of GOT2 by providing pyruvate, maintaining redox homeostasis and tumor growth in vivo.

bioRxiv · Aug 7, 2020Cancer Biology