M. Takeichi

Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton

This study investigates how molecular chirality leads to cellular chirality in epithelial cells, revealing that concentric actomyosin filaments drive intracellular rotation.

Tracheal motile cilia in mice require CAMSAP3 for formation of central microtubule pair and coordinated beating

This study shows CAMSAP3 is essential for forming the central microtubule pair in tracheal motile cilia and enabling coordinated beating in mice.

CAMSAP2 organizes a γ-tubulin-independent microtubule nucleation centre

The paper shows CAMSAP2 nucleates microtubules from soluble β-tubulin without γ-tubulin, reducing the nucleation barrier and forming aster-like structures.

Celsr1 and CAMSAP3 differently regulate intercellular and intracellular cilia orientation in oviduct multiciliated cells

This study shows Celsr1 and CAMSAP3 regulate BB orientation in MCCs differently, with CAMSAP3 critical for intracellular coordination and Celsr1 dispensable for individual cell orientation.

Adherens junction serves to generate cryptic lamellipodia required for collective migration of epithelial cells

The paper investigates how adherens junctions generate cryptic lamellipodia in epithelial cells, enabling collective migration by recruiting actin regulators and facilitating follower cell trailing.