Structural basis of Irgb6 inactivation by Toxoplasma gondii through the phosphorylation of switch I.
H. Okuma, Y. Saijo-Hamano, A. A. Sherif, E. Hoshizaki, N. Sakai, T. Kato, T. Imasaki, E. Nitta, M. Sasai, Y. Maniwa, H. Kosako, D. M. Standley, M. Yamamoto, R. Nitta
The paper reveals how Toxoplasma gondii inactivates Irgb6 through ROP18-mediated phosphorylation, preventing its function in host defense.
bioRxiv · Oct 31, 2022 · PreprintMicrobiology