T. Fujimori

Mechanical transapical coupling of endometrial epithelial cells during implantation

The paper demonstrates mechanical coupling between epithelial cells at apical-apical surfaces during implantation, mediated by extracellular matrix and tight junction molecules.

Effective mechanical potential of cell-cell interaction in tissues harboring cavity and in cell sheet toward morphogenesis

The paper evaluates an image-based method for inferring cell-cell interaction potentials in tissues with cavities and cell sheets, showing it can reproduce morphological structures.

Tight junction membrane proteins regulate the mechanical resistance of the apical junctional complex

This study shows that tight junction membrane proteins regulate the mechanical resistance of apical junctions in epithelial cells by maintaining ZO-1 molecule organization.

Effective mechanical potential of cell-cell interaction explains three-dimensional morphologies during early embryogenesis

The paper develops a method to infer mechanical forces of cell-cell interactions and shows that quantitative differences in effective pairwise potentials explain morphological differences in early embryos.

Discovery of the apiosyltransferase, celery UGT94AX1 that catalyzes the biosynthesis of a flavone glycoside, apiin

This paper identifies celery UGT94AX1 as the apiosyltransferase responsible for apiin biosynthesis and characterizes its substrate specificity and key residues.

Differential cellular stiffness contributes to tissue elongation on an expanding surface

This study investigates how differential cellular stiffness, through area elasticity, influences tissue elongation in an expanding environment, supported by comparisons to mouse notochord development.

Tracheal motile cilia in mice require CAMSAP3 for formation of central microtubule pair and coordinated beating

This study shows CAMSAP3 is essential for forming the central microtubule pair in tracheal motile cilia and enabling coordinated beating in mice.

Force-dependent remodeling of cytoplasmic ZO-1 condensates contributes to cell-cell adhesion

The paper shows that ZO-1 condensates in mouse embryos dissolve under mechanical stress, promoting cell-cell adhesion during development.

Micro-topographical guidance of macropinocytic signaling patches

The paper shows that micro-topography guides macropinocytic signaling patches in Dictyostelium, with PI3K-dependent nucleation and confinement at convex and concave surfaces, respectively.

Celsr1 and CAMSAP3 differently regulate intercellular and intracellular cilia orientation in oviduct multiciliated cells

This study shows Celsr1 and CAMSAP3 regulate BB orientation in MCCs differently, with CAMSAP3 critical for intracellular coordination and Celsr1 dispensable for individual cell orientation.

Isotropic expansion of external environment induces tissue elongation and collective cell alignment

This study shows isotropic expansion of external environments can cause tissue elongation and collective cell alignment through passive cell movement.

Tissue self-organization based on collective cell migration by contact activation of locomotion and chemotaxis

This study identifies a contact-based migration mechanism in Dictyostelium cells that competes with chemotaxis, revealing new rules for cell sorting and collective migration.