Author

M. van den Broek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cancer Biology· 2 Bioengineering· 1 Evolutionary Biology· 1 Immunology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:cell type annotation· 7 Organism:yeast· 5 Assay:whole-genome sequencing· 4 Organism:human· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2

Frequent Co-Authors

J. T. Pronk· 3 shared J.-M. G. Daran· 3 shared B. Becher· 2 shared H. Moch· 2 shared J.-M. Daran· 2 shared K. Silina· 2 shared M. Vermeer· 2 shared N. Brouwers· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersMicrobiology

J. T. Pronk

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Author profile →

9 papers

Recent·Most cited

Multi-resolution deep learning characterizestertiary lymphoid structures in solid tumors

M. van Rijthoven, S. Obahor, F. Pagliarulo, M. van den Broek, P. Schraml, H. Moch, J. van der Laak, F. Ciompi, K. Silina

This paper introduces HookNet-TLS, a deep learning model for automated TLS quantification in cancer pathology slides, achieving human-level performance and prognostic associations.

bioRxiv · Apr 3, 2023Pathology

Long-read direct RNA sequencing of the mitochondrial transcriptome of Saccharomyces cerevisiae reveals condition-dependent intron turnover

C. C. Koster, A. Kleefeldt, M. van den Broek, M. Luttik, J.-M. G. Daran, P. Daran-Lapujade

This study uses long-read RNA sequencing to analyze mitochondrial transcriptomes in yeast under different growth conditions, revealing condition-dependent intron turnover patterns.

bioRxiv · Jan 19, 2023 · PreprintMicrobiology

Acquired resistance to anti-PD1 therapy in patients with NSCLC reveals changes in T cell phenotypes and MET amplification

S. Hiltbrunner, L. Cords, S. Kasser, S. N. Freiberger, S. Kreutzer, N. C. Toussaint, L. Grob, I. Opitz, M. Messerli, M. Zoche, A. Soltermann, M. Rechsteiner, M. van den Broek, B. Bodenmiller, A. Curioni-Fontecedro

This study identifies two patterns of acquired resistance to anti-PD1 therapy in NSCLC patients, including reduced T cell infiltration and MET amplification.

bioRxiv · Apr 8, 2022 · PreprintCancer Biology

Modular, synthetic chromosomes as new tools for large scale engineering of metabolism

E. Postma, E.-J. Hassing, V. Mangkusaputra, J. Geelhoed, P. de la Torre, M. van den Broek, C. Mooiman, M. Pabst, J.-M. Daran, P. Daran-Lapujade

This study demonstrates the use of modular neochromosomes in yeast to engineer metabolic pathways for anthocyanin production.

bioRxiv · Oct 4, 2021Bioengineering

Conventional NK cells and tissue-resident ILC1s join forces to control liver metastasis

L. Ducimetiere, G. Lucchiari, G. Litscher, M. Nater, L. Heeb, N. G. Nunez, L. Wyss, D. Burri, M. Vermeer, J. Gschwend, A. Moor, B. Becher, M. van den Broek, S. Tugues

This study identifies the non-redundant roles of conventional NK cells and tissue-resident ILC1s in controlling liver metastasis through distinct functions in seeding and outgrowth.

bioRxiv · Jul 17, 2020Immunology

Adaptive laboratory evolution and reverse engineering of single-vitamin prototrophies in Saccharomyces cerevisiae.

T. Perli, D. P. I. Moonen, M. van den Broek, J. T. Pronk, J.-M. G. Daran

This paper shows that adaptive laboratory evolution can enable Saccharomyces cerevisiae to grow without individual B-vitamins, and identifies key mutations responsible for this trait.

Applied and Environmental Microbiology · Jun 2, 2020Peer-reviewedMicrobiology

CD39+PD-1+CD8+ T cells mediate metastatic dormancy in breast cancer

P. Tallon de Lara, H. Castanon, M. Vermeer, N. Nunez, K. Silina, B. Sobottka, J. Urdinez, V. Cecconi, F. Movahedian Attar, S. Hiltbrunner, I. Glarner, H. Moch, S. Tugues, B. Becher, M. van den Broek

This study identifies CD39+PD-1+CD8+ T cells as critical for metastatic dormancy in breast cancer, showing their role in suppressing tumor growth and their potential as a biomarker and immunotherapy target.

bioRxiv · Jun 2, 2020Cancer Biology

Maltotriose consumption by hybrid Saccharomyces pastorianus is heterotic and results from regulatory cross-talk between parental sub-genomes

N. Brouwers, A. Brickwedde, A. Gorter de Vries, M. van den Broek, S. M. Weening, L. F. van den Eijnden, J. A. Diderich, F.-Y. Bai, J. T. Pronk, J.-M. Daran

This study shows that maltotriose consumption in S. pastorianus hybrids arises from regulatory cross-talk between parental sub-genomes, demonstrating heterosis in this industrially relevant trait.

bioRxiv · Jun 28, 2019 · PreprintMicrobiology

In vivo recombination of Saccharomyces eubayanus maltose-transporter genes yields a chimeric transporter that enables maltotriose fermentation

N. Brouwers, A. R. Gorter de Vries, M. van den Broek, S. M. Weening, T. D. Elink Schuurman, N. G. A. Kuijpers, J. T. Pronk, J.-M. G. Daran

This study enables maltotriose fermentation in Saccharomyces eubayanus by evolving a chimeric transporter gene through recombination of existing maltose-transporter genes.

bioRxiv · Sep 27, 2018Evolutionary Biology