Author

M. Wachtel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 3 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1

Frequent Co-Authors

A. G. Henssen· 2 shared D. Gürgen· 2 shared S. G. Danielli· 2 shared A. Eggert· 1 shared A. G. Patel· 1 shared A. J. De Micheli· 1 shared A. Kühl· 1 shared A. M. Wengner· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersCancer Biology

A. G. Henssen

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4 papers

Recent·Most cited

Single cell transcriptomic profiling identifies tumor-acquired and therapy-resistant cell states in pediatric rhabdomyosarcoma

S. G. Danielli, Y. Wei, M. A. Dyer, E. Stewart, M. Wachtel, B. W. Schaefer, A. G. Patel, D. M. Langenau

This study identifies therapy-resistant and tumor-acquired cell states in pediatric rhabdomyosarcoma using single-cell RNA sequencing.

bioRxiv · Oct 13, 2023Cancer Biology

Elimusertib outperforms standard of care chemotherapy in preclinical patient-derived pediatric solid tumor models

F. F. Pusch, H. Dorado Garcia, R. Xu, D. Gürgen, Y. Bei, L. Brückner, C. Röefzaad, J. von Stebut, V. Bardinet, M. d. R. Chamorro Gonzalez, A. Eggert, J. H. Schulte, P. Hundsdörfer, G. Seifert, K. Haase, , A. G. Henssen

This paper evaluates elimusertib's preclinical efficacy in pediatric solid tumor models, finding it outperforms standard chemotherapy, especially in alveolar rhabdomysarcoma.

bioRxiv · Nov 10, 2022 · PreprintCancer Biology

Single-cell mapping of tumor heterogeneity in pediatric rhabdomyosarcoma reveals developmental signatures with therapeutic relevance

S. G. Danielli, E. Porpiglia, A. J. De Micheli, N. Navarro, M. J. Zellinger, I. Bechtold, S. Kisele, L. Volken, J. G. Marques, S. Kasper, P. K. Bode, A. G. Henssen, D. Gürgen, J. Roma, P. Bühlmann, , B. W. Schäfer

This study maps tumor heterogeneity in pediatric rhabdomyosarcoma using single-cell data, revealing developmental signatures and identifying the RAS pathway as a therapeutic target.

bioRxiv · Apr 20, 2022 · PreprintCancer Biology

Miswired enhancer logic drives translocation positive rhabdomyosarcoma

B. E. Gryder, M. Wachtel, K. Chang, O. E. Demerdash, N. G. Aboreden, W. Ewert, S. Pomella, W. Mohammed, R. Rota, J. S. Wei, Y. Song, B. Schaefer, C. R. Vakoc, J. Khan

The paper identifies a miswired enhancer logic driven by PAX3-FOXO1 translocation in rhabdomyosarcoma, disrupting normal transcription factor regulation and promoting undifferentiated proliferation.

bioRxiv · Sep 6, 2019 · PreprintCancer Biology