M. Fujita

Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1

This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.

The heparin-binding domain of VEGF165 directly binds to integrin αvβ3 and plays a critical role in signaling.

This study identifies the heparin-binding domain of VEGF165 as critical for integrin αvβ3 binding and signaling, showing its role in mitogenic activity.

Psychosocial experiences are associated with human brain mitochondrial biology

This study links psychosocial experiences to mitochondrial biology in the human brain, finding positive experiences correlate with higher OxPhos machinery abundance and negative experiences with lower abundance.

Evolution of wheat blast resistance gene Rmg8 accompanied by differentiation of variants recognizing the powdery mildew fungus

The paper traces the evolutionary origin of wheat blast resistance gene Rmg8 and shows its ability to recognize both wheat blast and powdery mildew pathogens.

Breeding of a near-isogenic wheat line resistant to wheat blast at both seedling and heading stages through incorporation of Rmg8

This study introduces Rmg8 into a wheat cultivar to create near-isogenic lines resistant to wheat blast at both seedling and heading stages, showing broader resistance than existing genetic resources.

Rapid and Efficient Ambient Temperature X-ray Crystal Structure Determination at Turkish Light Source

The paper introduces a plate-reader module for rapid ambient temperature X-ray crystallography at a home source and reports the first lysozyme structure determined at Turkish DeLight.

Cryogenic X-ray crystallographic studies of biomacromolecules at Turkish Light Source: Turkish DeLight

The paper describes the setup and application of a new X-ray crystallography facility in Turkey for structural analysis of biomacromolecules using lysozyme as a model.

Pro-inflammatory chemokines CCL5, CXCL12, and CX3CL1 bind to and activate platelet integrin αIIbβ3 in an allosteric manner.

This study identifies CCL5, CXCL12, and CX3CL1 as novel ligands for platelet integrin αIIbβ3 that allosterically activate it, linking inflammation to thrombosis.

Functional roles of multiple Ton complex genes in a Sphingobium degrader of lignin-derived aromatic compounds

The paper investigates the role of Ton complex genes in the uptake of lignin-derived aromatics in Sphingobium sp. strain SYK-6, showing that the tonB1 operon enhances aromatic conversion.

CLPTM1L is a lipid scramblase involved in glycosylphosphatidylinositol biosynthesis

The paper identifies CLPTM1L as a lipid scramblase essential for translocating glucosaminyl-phosphatidylinositol across the ER membrane during GPI biosynthesis.

A breast cancer patient-derived xenograft and organoid platform for drug discovery and precision oncology

The paper develops patient-derived xenografts and organoids for breast cancer to enable drug screening and precision oncology, showing efficacy of an FDA-approved drug in a clinical case.

Structural insight into host plasma membrane association and assembly of HIV-1 Matrix protein

This study presents crystal structures of HIV-1 MA domain bound to IP6, revealing its binding mode and interaction with PIP2, providing insights into virion assembly.

TRF2-mediated ORC recruitment underlies telomere stability upon DNA replication stress

This study shows that TRF2-mediated ORC recruitment helps maintain telomere stability under replication stress in human cells.

Preventing post-surgical cardiac adhesions with a catechol-functionalized oxime hydrogel

This paper develops a catechol-functionalized oxime hydrogel to prevent post-surgical cardiac adhesions, showing improved tissue retention and reduced adhesion severity in animal models.

Variation and process of life history evolution in insular dwarfism as revealed by a natural experiment

The paper investigates life history evolution in insular dwarfism using deer populations, finding slower growth and delayed maturity in more isolated populations.

Iron acquisition system of Sphingobium sp. strain SYK-6, a degrader of lignin-derived aromatic compounds

This study identifies the iron acquisition system in Sphingobium sp. strain SYK-6, revealing key transporters and regulatory mechanisms involved in iron uptake under limited conditions.

Cross-talks of glycosylphosphatidylinositol biosynthesis with glycosphingolipid biosynthesis and ER-associated degradation

The paper identifies B3GALT4's dual role in GPI and glycosphingolipid biosynthesis and shows ER-associated degradation suppresses GPI biosynthesis when GPI transfer to proteins is defective.

Serial femtosecond X-ray diffraction of HIV-1 Gag MA-IP6 microcrystals at ambient temperature

This study uses serial femtosecond X-ray crystallography to analyze HIV-1 Gag MA-IP6 microcrystals at ambient temperature, achieving high-resolution diffraction data.

Comprehensive Analysis of Indels in Whole-genome Microsatellite Regions and Microsatellite Instability across 21 Cancer Types

The paper analyzes microsatellite mutations across 21 cancer types, identifies MSI cancers, and finds factors influencing mutation rates and functional impacts.