Author

M.-H. Huynh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 6

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Assay:imaging· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

V. B. Carruthers· 6 shared A. J. Schultz· 2 shared F. Wang· 2 shared G. Kannan· 2 shared S. Lourido· 2 shared T. L. Schultz· 2 shared A. Gomes· 1 shared A. J. Guerra· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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6 shared papersMicrobiology

V. B. Carruthers

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Author profile →

6 papers

Recent·Most cited

Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors

F. Wang, M. J. Holmes, H. J. Hong, P. Thaprawat, G. Kannan, M.-H. Huynh, T. L. Schultz, M. H. Licon, S. Lourido, W. Dong, J. Brito Querido, W. J. Sullivan, S. E. O Leary, V. B. Carruthers

This study identifies eIF1.2 as a regulator of Toxoplasma gondii differentiation by controlling the translation of key bradyzoite factors.

bioRxiv · Nov 3, 2023 · PreprintMicrobiology

A conserved complex of microneme proteins mediates rhoptry discharge in Toxoplasma

S. Sidik, D. Valleau, Y. Acevedo-Sanchez, L. C. Godoy, C. F. A. Pasaje, M.-H. Huynh, V. B. Carruthers, J. C. Niles, S. Lourido

The paper identifies a conserved microneme protein complex, CLAMP-SPATR-CLIP, essential for rhoptry discharge in Toxoplasma gondii.

bioRxiv · Nov 28, 2022 · PreprintMicrobiology

Toxoplasma gondii excretion of glycolytic products is associated with acidification of the parasitophorous vacuole during parasite egress

M.-H. Huynh, V. B. Carruthers

This paper directly measures pH changes in the parasitophorous vacuole during Toxoplasma gondii egress and identifies formate-nitrite transporters as contributors to vacuolar acidification.

bioRxiv · Nov 25, 2021Microbiology

Toxoplasma gondii Toxolysin 4 contributes to efficient parasite egress from host cells

M.-H. Huynh, M. Roiko, A. Gomes, E. N. Schinke, A. J. Schultz, S. Agrawal, C. A. Olleig, T. R. Sexton, J. M. Beauchamp, J. Laliberte, K. K. Sivaraman, L. B. Hersh, S. McGowan, V. B. Carruthers

This study identifies Toxolysin 4 (TLN4) as a metalloproteinase necessary for efficient Toxoplasma gondii egress from host cells.

bioRxiv · May 13, 2021Microbiology

A role for Toxoplasma gondii chloroquine resistance transporter in bradyzoite viability and digestive vacuole maintenance

G. Kannan, M. Di Cristina, A. J. Schultz, M.-H. Huynh, F. Wang, T. L. Schultz, M. Lunghi, I. Coppens, V. B. Carruthers

This study shows that the Toxoplasma gondii chloroquine resistance transporter (TgCRT) is essential for maintaining the digestive vacuole and bradyzoite viability, suggesting it as a potential target for treating chronic Toxoplasma infection.

bioRxiv · May 24, 2019Microbiology

Structural basis of Toxoplasma gondii Perforin-Like Protein 1 membrane interaction and activity during egress

A. J. Guerra, O. Zhang, C. M. E. Bahr, M.-H. Huynh, J. DelProposto, W. C. Brown, Z. Wawrzak, N. M. Koropatkin, V. B. Carruthers

This study identifies the structural basis of TgPLP1 membrane interaction and its role in parasite egress by showing a hydrophobic loop insertion into the membrane is essential for cytolytic activity.

bioRxiv · Sep 2, 2018Microbiology