Author

Melinda S. McCarty

University of Tennessee Health Science Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioinformatics· 1 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Approach:statistical model· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1

Frequent Co-Authors

Arthur G. CentenoiD· 3 shared Jesse F. Ingels· 3 shared Lu LuiD· 3 shared Megan K. MulliganiD· 3 shared Robert W. WilliamsiD· 3 shared David George AshbrookiD· 2 shared Evan G. WilliamsiD· 2 shared Johan H. AuwerxiD· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersGenetics

Arthur G. CentenoORCID

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Author profile →

3 papers

Recent·Most cited

Gene-by-environmental modulation of longevity and weight gain in the murine BXD family

Suheeta Roy, Maroun S. Bou Sleiman, Pooja Jha, Jesse F. Ingels, Casey J. Chapman, Melinda S. McCarty, Jesse Dylan Ziebarth, Michael Hook, Anna Sun, Wenyuan Zhao, Jinsong Huang, Sarah M. Neuner, Lynda A. Wilmott, Thomas M. Shapaker, Arthur G. Centeno, , Robert W. Williams

The paper examines how diet and genetics interact to affect longevity and weight gain in mice, finding that genetic differences significantly influence the impact of high-fat diets on lifespan.

Nature Metabolism · Sep 22, 2021Peer-reviewedGenetics

Computational approaches towards reducing contamination in single-cell RNA-seq data

Siamak Yousefi, Hao Chen, Jesse F. Ingels, Melinda S. McCarty, Arthur G. Centeno, Sumana R. Chintalapudi, Megan K. Mulligan, Pete A. Williams, Simon W. M. John, Bryan William Jones, Monica M. Jablonski, TJ Hollingsworth, Eldon E. Geisert, Lu Lu, Robert W. Williams

The paper presents two computational methods to reduce contamination in single-cell RNA-seq data, improving clustering and biological interpretation.

bioRxiv · Jul 15, 2020 · PreprintBioinformatics

The expanded BXD family of mice: A cohort for experimental systems genetics and precision medicine

David George Ashbrook, Danny Arends, Pjotr Prins, Megan K. Mulligan, Suheeta Roy, Evan G. Williams, Cathleen M. Lutz, Alicia Valenzuela, Casey J. Bohl, Jesse F. Ingels, Melinda S. McCarty, Arthur G. Centeno, Reinmar Hager, Johan H. Auwerx, Śaunak Sen, , Robert W. Williams

BXD mouse family doubled to 150 inbred strains segregating over 6 million variants, with roughly 10,000 located recombinations and a public phenome exceeding 7000 traits.

bioRxiv · Jul 8, 2019 · PreprintGenomics