The methyl-CpG-binding protein 2 inhibits cGAS-associated signaling
Hanane Chamma, Soumyabrata Guha, Roger-Junior Eloiflin, Adeline Augereau, Pierre Le Hars, Moritz Schüssler, Yasmine Messaoud-Nacer, Mohammad Salma, Joe McKellar, Joanna Re, Morgane Chemarin, Arnaud Carrier, Michael A. Disyak, Clara Taffoni, Robin Charpentier, , Nadine Laguette
This study shows that MECP2 inhibits cGAS signaling by exporting to the cytosol upon dsDNA detection, dampening inflammation and antiviral responses.
Nature Communications · Nov 7, 2025Peer-reviewedImmunology