Author

Michael Constanzo

University of Toronto

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:benchmarking· 1 Assay:CRISPR screen· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:statistical model· 1 Organism:yeast· 1

Frequent Co-Authors

Charles M. BooneiD· 2 shared Alexander Weiss· 1 shared Amy H.Y. TongiD· 1 shared Amy Huei-Yi Lee· 1 shared Anastasia BaryshnikovaiD· 1 shared Andrea Habsid· 1 shared Ashwin SeetharamaniD· 1 shared Avery J. C. NoonaniD· 1 shared

Activity by Year

2017-2018 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMicrobiology

Charles M. BooneORCID

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Yeast Genomic Screens Identify Kinesins as Potential Targets of the Pseudomonas syringae Type III Effector, HopZ1a

Amy Huei-Yi Lee, D. Patrick Bastedo, Timothy Lo, Maggie A. Middleton, Ji-Young Youn, Inga Kireeva, Jee Yeon Lee, Sara Sharifpoor, Anastasia Baryshnikova, Jianfeng Zhang, Pauline W. Wang, Sergio G. Peisajovich, Michael Constanzo, Brenda J. Andrews, Charles M. Boone, , David S. Guttman

The paper identifies HopZ1a, a T3SE from Pseudomonas syringae, as an acetyltransferase that targets plant kinesins to disrupt microtubule networks through yeast genetic and interaction screens.

bioRxiv · Jul 9, 2018 · PreprintMicrobiology

Evaluation and Design of Genome-wide CRISPR/Cas9 Knockout Screens

Traver Hart, Amy H.Y. Tong, Katie Chan, Jolanda S. van Leeuwen, Ashwin Seetharaman, Michael Aregger, Megha Chandrashekhar, Nicole Hustedt, Sahil Seth, Avery J. C. Noonan, Andrea Habsid, Olga S. Sizova, Lyudmila Nedyalkova, Ryan Climie, Keith A. Lawson, , Jason Moffat

The paper evaluates CRISPR/Cas9 knockout screens in human cell lines and designs an optimized gRNA library to improve gene knockout efficiency and accuracy.

bioRxiv · Mar 16, 2017 · PreprintSystems Biology