Author

Michele D. Sobolewski

University of Pittsburgh

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Elias Konstantine HalvasiD· 2 shared Jana L. JacobsiD· 2 shared John M. CoffiniD· 2 shared John W. MellorsiD· 2 shared Mary F. KearneyiD· 2 shared Michael J. BaleiD· 2 shared Wei ShaoiD· 2 shared Adam A. CapoferriiD· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Elias Konstantine HalvasORCID

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Author profile →

2 papers

Recent·Most cited

HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA

Adam A. Capoferri, Ann P. Wiegand, Feiyu F. Hong, Jana L. Jacobs, Jonathan Spindler, Andrew Musick, Michael J. Bale, Wei Shao, Michele D. Sobolewski, Anthony Richard Cillo, Brian T. Luke, Christine M. Fennessey, Robert J. Gorelick, Rebecca Hoh, Elias Konstantine Halvas, , Mary F. Kearney

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

Proceedings of the National Academy of Sciences · Aug 27, 2024Peer-reviewedMicrobiology

HIV-1 Viremia Not Suppressible By Antiretroviral Therapy Can Originate from Large T-Cell Clones Producing Infectious Virus

Elias Konstantine Halvas, Kevin W. Joseph, Leah D. Brandt, Shuang Guo, Michele D. Sobolewski, Jana L. Jacobs, Camille Tumiotto, John K. Bui, Joshua C. Cyktor, Brandon F. Keele, Gene D. Morse, Michael J. Bale, Wei Shao, Mary F. Kearney, John M. Coffin, , John W. Mellors

The paper identifies large T-cell clones producing infectious HIV-1 virus as a source of non-suppressible viremia despite ART adherence and no drug resistance.

Journal of Clinical Investigation · Oct 4, 2020Peer-reviewedGenomics