Author

Robert J. Gorelick

Frederick National Laboratory for Cancer ResearchORCID 0000-0002-1773-9085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:metagenomics· 1

Frequent Co-Authors

Adam A. CapoferriiD· 1 shared Andreas MeyerhansiD· 1 shared Andrew MusickiD· 1 shared Ann P. Wiegand· 1 shared Anthony Richard CilloiD· 1 shared Brian T. LukeiD· 1 shared Carine TisnéiD· 1 shared Christine M. FennesseyiD· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

Adam A. CapoferriORCID

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2 papers

Recent·Most cited

HIV-1 control in vivo is related to the number but not the fraction of infected cells with viral unspliced RNA

Adam A. Capoferri, Ann P. Wiegand, Feiyu F. Hong, Jana L. Jacobs, Jonathan Spindler, Andrew Musick, Michael J. Bale, Wei Shao, Michele D. Sobolewski, Anthony Richard Cillo, Brian T. Luke, Christine M. Fennessey, Robert J. Gorelick, Rebecca Hoh, Elias Konstantine Halvas, , Mary F. Kearney

The paper compares the fraction and total number of HIV-infected cells with unspliced RNA in controllers and non-controllers, finding that viremic control is linked to fewer infected cells, not a lower fraction of infected cells with HIV usRNA.

Proceedings of the National Academy of Sciences · Aug 27, 2024Peer-reviewedMicrobiology

The HIV-1 ribonucleoprotein dynamically regulates its condensate behavior and drives acceleration of protease activity through membraneless granular phase separation

Sébastien Lyonnais, S. Kashif Sadiq, Cristina Lorca-Oró, Laure Dufau, Sara Nieto-Márquez, Tuixent Escribà, Natalia Gabrielli, Xiao Tan, Mohamed Ouizougun-Oubari, Josephine Okoronkwo, Michèle Reboud‐Ravaux, José María Gatell, Roland Marquet, Jean‐Christophe Paillart, Andreas Meyerhans, , Gilles Mirambeau

The paper investigates how HIV-1's RNP granules regulate protease activity through phase separation, revealing key RNA-binding motifs and their role in viral maturation.

bioRxiv · Oct 26, 2021 · PreprintMolecular Biology