INSULIN-LIKE GROWTH FACTOR I SENSITIZATION REJUVENATES SLEEP PATTERNS IN OLD MICE
Jonathan Adrian Zegarra-Valdivia, Jansen Fernandes, María Estrella Fernández de Sevilla, Ángel Trueba-Sáiz, Jaime Pignatelli, Kentaro Suda, Laura Martinez‐Rachadell, Ana Maria Fernandez, Julio Esparza, Miguel Vega, Ángel Núñez, Ignacio Torres‐Alemán
This study shows that IGF-I signaling to orexin neurons is impaired in old mice, leading to sleep disturbances, and that IGF-IR sensitizer AIK3a305 restores sleep patterns.
GeroScience · May 23, 2022Peer-reviewedNeuroscience