Chromatin-Assisted Targeting Enables Precise DNA Methylation Editing in Plants
Yan He, Ming Wang, Tyler J. Buckley, Brandon A. Boone, Erika Li, Janice Yerin Shin, Nicholas Alvarado, Bohao Xu, Anh Nguyen, Shuya Wang, Yuxing Zhou, Suhua Feng, Steven E. Jacobsen
SunTag-NOVA, a SunTag-MQ1v editor adding TRBIP1 and an oligomerizing CHLAMY domain, methylates and silences FWA, FT and TMM in Arabidopsis without the genome-wide off-target methylation seen with TRBIP1 alone.
bioRxiv · Aug 26, 2026 · PreprintPlant Biology✦ In-depth digest