Mitophagy Facilitates Cytosolic Proteostasis to Preserve Cardiac Function
David R. Rawnsley, Moydul Islam, Chen Zhao, Xumin Guan, Yasaman Kargar Gaz Kooh, Adelita D. Mendoza, Honora Navid, Minu Kumari, Phalgun Pandi, John T. Murphy, Jess Nigro, Attila Kovacs, Lina Greenberg, Xiucui Ma, Michael J. Greenberg, , Abhinav Diwan
This study shows that mitophagy removes cytosolic protein aggregates in cardiac myocytes, preventing cardiomyopathy, and that TRAF2 modulation affects this process.
Circulation Research · Aug 26, 2026Peer-reviewedCell Biology