S. Mandal

Carbon nanoparticle exposure strengthens water-relation parameters by stimulating abscisic acid pathway and aquaporins genes in rice

This study shows carbon nanoparticles improve rice growth and water use efficiency by enhancing the ABA pathway and aquaporin gene expression, leading to better stress tolerance.

Carbonized Tetracycline: a new class of nanomaterial with tuneable antioxidant, reduced cytotoxicity, immunomodulatory, and osteogenic properties

This paper converts tetracycline into carbonized nanomaterials with improved antioxidant and osteogenic properties while reducing cytotoxicity and adverse effects.

Modelling termites tunnelling and decision-making behaviors

This study models termites' tunnelling and direction-changing behaviors using a mathematical model and decision tree, validated with experimental data on two termite species.

WASP facilitates tumor mechanosensitivity in T lymphocytes

This study identifies WASP as a key mediator of mechanosensitivity in CTLs, linking mechanical cues from target cells to TCR signaling and immune response.

Drug-bacterial membrane interactions: A Tale of two force fields

This study compares two force fields for modeling mycolic acid monolayers to assess drug permeability and interaction modes in tuberculosis research.

DNA Tetrahedral Nanocages as a Promising Nanocarrier for Dopamine Delivery in Neurological Disorders

This study investigates DNA tetrahedral nanocages as a dopamine carrier for treating neurological disorders, showing their ability to deliver dopamine to cells and zebrafish embryos.

Genetic and transcriptomic analysis of hyphal constriction based on a novel assay method in the rice blast fungus

The paper introduces an in vitro assay to study hyphal constriction in Magnaporthe oryzae, identifying transcriptional changes and a potential histone modification role in this process.

PD-L1 activity is associated with partial EMT and metabolic reprogramming in carcinomas

The paper identifies a link between PD-L1 activity, partial EMT, and metabolic reprogramming in carcinomas using transcriptomic data and single-cell RNA-seq.

A low-cost, open-source evolutionary bioreactor and its educational use

The paper introduces a low-cost, open-source morbidostat for educational use, validated through bacterial resistance experiments and student engagement.

Specialized metabolism by trichome-preferentially-expressed Rubisco and fatty acid synthase components

The paper identifies and validates two trichome-preferentially-expressed genes involved in acylsugar biosynthesis in solanaceous plants through gene expression analysis and virus-induced gene silencing.

ASTF1, an AP2/ERF-family transcription factor and ortholog of cultivated tomato LEAFLESS, is required for acylsugar biosynthesis

This study identifies ASTF1 as a transcription factor regulating acylsugar biosynthesis in solanaceous plants and shows its conserved role across species.

Cooperative escape in ants and robots

This study examines cooperative escape behavior in ants and robots, showing how simple rules lead to collective problem-solving in dynamic environments.

Immunosuppressive traits of the hybrid epithelial/mesenchymal phenotype

The paper investigates immune-evasive strategies of hybrid epithelial/mesenchymal (E/M) cells using a regulatory network model and RNA-seq data, showing they can exhibit high PD-L1 levels without full EMT.

Rapid Kinetic Fingerprinting of Single Nucleic Acid Molecules by a FRET-based Dynamic Nanosensor

This paper introduces iSiMREPS, a method for rapid, single-molecule detection of miRNAs and ctDNAs with high specificity and sensitivity, achieving detection in 10 seconds.

A mechanistic model captures the emergence and implications of non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells

This study develops a mechanistic model showing how non-genetic heterogeneity and reversible drug resistance in ER+ breast cancer cells arise through EMT dynamics and phenotypic plasticity, suggesting MET inducers as potential therapeutic targets.

In-Vitro Fluorescence Microscopy Studies Show Retention of Spike-Protein (SARS-Cov-2) on Cell Membrane in the Presence of Amodiaquin Dihydrochloride Dihydrate Drug

This study investigates how Amodiaquin dihydrochloride dihydrate affects SARS-CoV-2 S-protein entry into cells, showing prolonged membrane retention and non-endocytic entry.

A novel benzoxaborole works by targeting FabI in Escherichia coli

This study identifies a benzoxaborole compound that targets FabI in E. coli, showing resistance mutations occur in FabI and dependence on NAD+ for activity.

Investigating epithelial-mesenchymal heterogeneity of tumors and circulating tumor cells with transcriptomic analysis and biophysical modeling

This study investigates the relationship between epithelial-mesenchymal plasticity in tumors and circulating tumor cells using transcriptomic analysis and biophysical modeling, finding no consistent correlation between EMT traits in tumors and CTCs.

Sedimentation rate and organic matter dynamics shape microbiomes across a continental margin

The paper examines how sedimentation rates and organic matter dynamics influence microbiome structure and function in different oxygen minimum zones along the Arabian Sea margin.

Dynamics of the COVID -19 Related Publications

This paper analyzes the dynamics of COVID-19 related publications across PubMed, Elsevier, and ResearchGate, finding rapid growth in publication rates and geographic author distribution.

Targeted immuno-antiretroviral HIV therapeutic approach to provide dual protection and boosts cellular immunity: A proof-of-concept study

This study develops a dual-action nanoformulation combining a CCR5 monoclonal antibody and antiretrovirals to enhance HIV protection and immune response, showing improved efficacy compared to individual components.

Free-ranging dogs are capable of comprehending complex human pointing cues.

This study tests free-ranging dogs' ability to understand complex human pointing cues and finds they can comprehend distal pointing, though some show anxiety affecting responsiveness.

Metabolically-active obligate aerobes in anoxic (sulfidic) marine sediments

The paper identifies metabolically-active obligate aerobes in anoxic marine sediments by combining culture-dependent and -independent methods, revealing their survival through cryptic oxygen production.

Molecular mechanism of sulfur chemolithotrophy in the betaproteobacterium Pusillimonas ginsengisoli

This study identifies the molecular mechanism of thiosulfate oxidation in Pusillimonas ginsengisoli, revealing a unique pathway involving tetrathionate and glutathione.

Cryptic role of tetrathionate in the sulfur cycle: A study from Arabian Sea oxygen minimum zone sediments

The paper investigates the role of tetrathionate in the sulfur cycle of Arabian Sea OMZ sediments, revealing its microbial and geochemical sources and transformations.

Two pathways for thiosulfate oxidation in the alphaproteobacterial chemolithotroph Paracoccus thiocyanatus SST

This paper identifies two distinct pathways for thiosulfate oxidation in Paracoccus thiocyanatus SST: a Sox system and a Tetrathionate-Intermediate pathway, with the latter being more efficient for thiosulfate conversion.

Inorganic salts and compatible solutes help mesophilic bacteria inhabit the high temperature waters of a Trans-Himalayan sulfur-borax spring

The paper investigates how inorganic salts and compatible solutes enable mesophilic bacteria to thrive in high-temperature Trans-Himalayan hot springs by stabilizing macromolecules and maintaining cell viability.

ROS accumulation and associated cell death mediates susceptibility to Alternaria brassicae in Arabidopsis accessions

The paper investigates resistance mechanisms in Arabidopsis to Alternaria brassicae, finding that ROS accumulation and cell death correlate with susceptibility, and that RBOH D, E, F and JA/ET/ABA pathways influence defense.

Candidate Gene Networks for Acylsugar Metabolism and Plant Defense in Wild Tomato Solanum pennellii

The paper identifies candidate genes and networks involved in acylsugar metabolism and plant defense in Solanum pennellii through transcriptomic analysis and gene co-expression networks.

Ontogeny of familiarity with foraging landscape and foraging abilities in the tropical social wasp Ropalidia marginata

This study shows that Ropalidia marginata wasps develop spatial memory and foraging efficiency over time, despite spending less time foraging as they age.