Y. Matsumoto

Targeting dermatophyte Cdc42 and Rac GTPase signaling to hinder hyphal elongation and virulence

This study identifies Cdc42 and Rac GTPase inhibition as a strategy to block hyphal elongation and virulence in Trichophyton rubrum, with EHop-016 showing promise as an antifungal lead.

Acid-treated Staphylococcus aureus induces acute silkworm hemolymph melanization

This study shows acid-treated Staphylococcus aureus induces melanization in silkworm hemolymph, with S. aureus proteins playing a role in innate immune activation.

General remarks of the secondary promoter element regulating the genome replication of paramyxo- and filoviruses

The paper identifies distinct PE2 subcategories in paramyxoviruses and shows that four U-containing hexamer repeats are critical for filovirus genome replication.

Nitrate Assimilation Underlying Kleptoplasty

This study identifies RvNaRL, a nitrate reductase gene acquired via horizontal gene transfer in R. viridis, which enables nitrate assimilation despite its heterotrophic lineage.

oskar acts with the transcription factor Creb to regulate long-term memory in crickets

The paper shows oskar works with Creb to regulate long-term memory in crickets, supporting its evolutionary origin in neural functions.

Acute innate immune activation in silkworm by the human commensal bacterium Cutibacterium acnes

This study shows that Cutibacterium acnes induces melanization in silkworm hemolymph, indicating innate immune activation, while peptidoglycans are involved in this response.

An attenuated vaccinia vaccine encoding the SARS-CoV-2 spike protein elicits broad and durable immune responses, and protects cynomolgus macaques and human ACE2 transgenic mice from SARS-CoV-2 and its variants

This study develops a vaccinia-based vaccine encoding SARS-CoV-2 spike protein that induces broad and durable immunity, protecting against multiple variants in non-human primates and transgenic mice.

A comprehensive list of the replication promoters of Bunyavirales reveals a unique promoter structure in Nairoviridae differing from other virus families

The paper identifies a unique GC-rich promoter structure in Nairoviridae, distinguishing it from other Bunyavirales families, and provides a comprehensive list of replication promoters.

EPI-589, a redox-active neuroprotectant, potently protects cultured cells from oxidative stress and alleviates symptomatic and pathological progression of motor neuron disease in the wobbler mouse

This study shows EPI-589, a redox-active compound, protects cells from oxidative stress and delays motor neuron disease symptoms in wobbler mice.

Frequency of a nucleotide overhang at the 5' end of hemorrhagic fever mammarenavirus genomes in public sequence data

The paper examines the frequency of a 5' guanine overhang in mammarenavirus genomes and links it to their pathogenicity.

Quantitative evaluation of Mycobacterium abscessus clinical isolate virulence using a silkworm infection model

This study evaluates the virulence of M. abscessus clinical isolates using a silkworm infection model, finding significant variation in median lethal doses among isolates.

The Japanese wolf is most closely related to modern dogs and its ancestral genome has been widely inherited by dogs throughout East Eurasia

This study analyzes the genomes of Japanese wolves and dogs to show that Japanese wolves are closely related to modern dogs and contributed ancestry to East Eurasian dogs.

A possible stimulus to induce SPAWNING in Ezo abalone Haliotis discus hannai during a stormy condition: Fenton reaction induces spawning behavior

This study hypothesizes that Fenton reaction-generated hydroxyl radicals during stormy weather induce spawning behavior in Ezo abalone.

SARS-CoV-2 Spike Protein Interacts with Multiple Innate Immune Receptors

This study identifies multiple innate immune receptors that recognize SARS-CoV-2 spike protein through glycan-dependent interactions, suggesting potential therapeutic targets.

Genetic characterization of Streptococcus pyogenes emm 89 strains isolated in Japan from 2011 to 2019

The paper characterizes emm89 Streptococcus pyogenes strains from Japan, finding most belong to clade 3 and carry STSS-associated genes and SNPs.

Functionalized mesoporous silica nanoparticles for innovative boron-neutron capture therapy of resistant cancers

This study develops B-MSNs for BNCT to treat chondrosarcomas, showing DNA damage and cell death in radio-resistant CSCs.

Uncovering Staphylococcus aureus genes with roles in pathogenicity by silkworm infection model

This study identifies 11 S. aureus genes critical for virulence using a silkworm infection model, with nine also affecting virulence in mice.

Estrogen induces mammary ductal dysplasia.

This study shows estrogen can cause mammary ductal dysplasia in a mouse model and demonstrates that isoflavones can inhibit this effect.