Author

N. K. Wolf

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:gene regulatory network inference· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

B. R. Webber· 2 shared W. S. Lahr· 2 shared B. Moriarity· 1 shared B. S. Moriarity· 1 shared C. Blaj· 1 shared C. J. Nicolai· 1 shared C. M. Kariya· 1 shared C. O. Ndubaku· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersImmunology

B. R. Webber

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Author profile →

3 papers

Recent·Most cited

Powerful synergistic effects of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I-deficient and MHC I+ tumors

N. K. Wolf, C. Blaj, L. Picton, G. Snyder, L. Zhang, C. J. Nicolai, C. O. Ndubaku, S. M. McWhirter, K. C. Garcia, D. H. Raulet

The paper combines a STING agonist and an IL-2 superkine to enhance cancer immunotherapy, showing efficacy against both MHC I-deficient and MHC I+ tumors.

bioRxiv · Nov 2, 2021 · PreprintImmunology

Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

D. C. Palmer, B. R. Webber, Y. Patel, M. J. Johnson, C. M. Kariya, W. S. Lahr, M. R. Parkhurst, J. J. Gartner, T. D. Prickett, F. J. Lowery, R. J. Kishton, D. Gurusamy, Z. Franco, S. K. Vodnala, M. D. Diers, , N. P. Restifo

This study shows that CISH knockout in TIL enhances neoantigen reactivity and synergizes with PD1 blockade to improve tumor regression.

bioRxiv · Sep 24, 2020Immunology

Highly Multiplexed Genome Engineering Using CRISPR/Cas9 gRNA Arrays

M. Kurata, N. K. Wolf, W. S. Lahr, M. T. Weg, S. Lee, K. Hui, M. Shiraiwa, B. R. Webber, B. Moriarity

This paper develops a CRISPR/Cas9 gRNA array system to enable efficient multiplex genome engineering by delivering up to 10 gRNAs as a single transcript.

bioRxiv · May 25, 2018Bioengineering