Author

N. Kale

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 4 Approach:experimental assay· 3 Organism:mouse· 3 Organism:human· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

M. S. Sosa· 3 shared A. R. Nobre· 2 shared B. D. Khalil· 2 shared E. Farias· 2 shared J. A. Aguirre-Ghiso· 2 shared A. Ashworth· 1 shared A. Marson· 1 shared A. Rodriguez Martinez· 1 shared

Activity by Year

2021-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersCancer Biology

M. S. Sosa

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Genome-wide CRISPR screens of T cell exhaustion identify chromatin remodeling factors that limit T cell persistence

J. Belk, W. Yao, N. Ly, K. Freitas, Y.-T. Chen, Q. Shi, A. Valencia, E. Shifrut, N. Kale, K. Yost, C. Duffy, M. Hwee, Z. Miao, A. Ashworth, C. Mackall, , A. Satpathy

This study identifies chromatin remodeling factors that limit T cell persistence using CRISPR screens and shows their impact on anti-tumor immunity.

bioRxiv · Apr 20, 2022Immunology

Epigenetic reprogramming of DCCs into dormancy suppresses metastasis via restored TGFβ-SMAD4 signaling.

D. K. Singh, E. Farias, S. Carcamo, D. Hasson, D. Sun, J. Cheung, A. R. Nobre, N. Kale, M. S. Sosa, E. Bernstein, J. A. Aguirre-Ghiso

The paper shows that AZA+atRA treatment induces dormancy in DCCs by restoring TGFβ-SMAD4 signaling, suppressing lung metastasis.

bioRxiv · Aug 1, 2021Cancer Biology

A specific agonist of the orphan nuclear receptor NR2F1 suppresses metastasis through the induction of cancer cell dormancy

B. D. Khalil, R. Sanchez, T. Rahman, C. A. Rodriguez-Tirado, S. Moritsch, A. Rodriguez Martinez, B. Miles, E. Farias, M. Mezei, J. F. Cheung, A. R. Nobre, N. Kale, K. C. Sproll, M. S. Sosa, J. A. Aguirre-Ghiso

This study identifies a novel NR2F1 agonist, C26, that suppresses metastasis by inducing cancer cell dormancy through NR2F1 activation in HNSCC.

bioRxiv · Jan 30, 2021Cancer Biology

NR2F1 is a barrier to dissemination of early-evolved mammary cancer cells

C. A. Rodriguez Tirado, N. Kale, M. J. Carlini, N. Shrivastava, B. D. Khalil, J. J. Bravo-Cordero, M. Alexander, J. Ji, M. S. Sosa

The paper identifies NR2F1 as a barrier to early dissemination of HER2+ mammary cancer cells, showing its regulation by tumor suppressive and oncogenic pathways and its role in epithelial-mesenchymal transition.

bioRxiv · Jan 29, 2021 · PreprintCancer Biology