Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint
Y. Cohen-Sharir, J. M. McFarland, M. Abdusamad, C. Marquis, H. Tang, M. R. Ippolito, S. V. Bernhard, K. Laue, H. L. Malaby, A. Jones, M. Kazachkova, N. Lyons, A. Nagaraja, A. J. Bass, R. Beroukhim, , U. Ben-David
This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.
bioRxiv · Jun 18, 2020Cancer Biology