Author

S. V. Bernhard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Approach:statistical model· 2 Research Focus:cancer & tumor microenvironment· 1 Assay:clinical cohort / trial· 1

Frequent Co-Authors

Z. Storchova· 4 shared K. Keuper· 3 shared U. Ben-David· 2 shared A. J. Bass· 1 shared A. Jones· 1 shared A. Nagaraja· 1 shared A. Simon· 1 shared A. Tijhuis· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersCell Biology

Z. Storchova

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Author profile →

4 papers

Recent·Most cited

Genetic instability from a single S-phase after whole genome duplication

S. Gemble, R. Wardenaar, K. Keuper, N. Srivastava, M. Nano, A.-S. Mace, A. Tijhuis, S. V. Bernhard, D. C. J. Spierings, A. Simon, O. Goundiam, H. Hochegger, M. Piel, F. Foijer, Z. Storchova, R. Basto

This study shows that newly formed tetraploid human cells experience high DNA damage during the first S-phase, leading to abnormal karyotypes and genetic instability.

bioRxiv · Jul 16, 2021Cell Biology

Whole-genome duplication shapes the aneuploidy landscape of human cancers

K. Prasad, M. Bloomfield, H. Levi, K. Keuper, S. V. Bernhard, N. C. Baudoin, G. Leor, M. Giam, C. K. Wong, G. Rancati, Z. Storchova, D. Cimini, U. Ben-David

This study shows that whole-genome duplication (WGD) alters aneuploidy patterns in human cancers, leading to distinct recurrence and genetic interaction patterns between WGD- and WGD+ tumors.

bioRxiv · May 5, 2021Cancer Biology

USP28 and SPINT2 mediate cell cycle arrest after whole genome doubling

Z. Storchova, K. Seget-Trzensiok, S. V. Bernhard, C. Kuffer, D. B. Krastev, M. Theiss, K. Keuper, J.-E. Boekenkamp, M. Kschischo, F. Buchholz

The paper identifies USP28 and SPINT2 as factors that enable tetraploid cell survival by modulating cell cycle arrest and DNA damage responses.

bioRxiv · Sep 18, 2020 · PreprintCell Biology

Selective vulnerability of aneuploid human cancer cells to inhibition of the spindle assembly checkpoint

Y. Cohen-Sharir, J. M. McFarland, M. Abdusamad, C. Marquis, H. Tang, M. R. Ippolito, S. V. Bernhard, K. Laue, H. L. Malaby, A. Jones, M. Kazachkova, N. Lyons, A. Nagaraja, A. J. Bass, R. Beroukhim, , U. Ben-David

This study identifies aneuploid cancer cells as more vulnerable to spindle assembly checkpoint (SAC) inhibition and explores the underlying mechanisms.

bioRxiv · Jun 18, 2020Cancer Biology