The m6A reader IGF2BP2 directs immune-metabolic reprogramming in Leishmania amazonensis-infected macrophages
S. Zhang, H. Lecoeur, H. Varet, R. Legendre, N. Mahtal, C. Proux, N. Aulner, S. Short, C. Grandjean, P. Bousso, E. Prina, G. F. Spaeth
This study identifies IGF2BP2 as an m6A reader that stabilizes glycolytic transcripts in Leishmania-infected macrophages, promoting HIF-1-independent glycolysis and immune-metabolic reprogramming.
bioRxiv · Sep 8, 2022 · PreprintImmunology