Author

O. Grana-Castro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. Megias· 2 shared A. De Reynies· 1 shared A. Di Giannatale· 1 shared A. Hernandez-Lain· 1 shared A. Lluch· 1 shared A. Perez-Nunez· 1 shared A. Prat· 1 shared A. Sagrera· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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Curved chords = mutual co-authorship

2 shared papersCancer Biology

D. Megias

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Endoglin, a novel biomarker and therapeutical target to prevent malignant peripheral nerve sheath tumor growth and metastasis

T. Gonzalez-Munoz, A. Di Giannatale, S. Garcia-Silva, V. Santos, S. Sanchez-Redondo, C. Savini, O. Grana-Castro, C. Blanco, D. J. Pisapia, J. L. Peralto, C. Romagosa Perez-Portabella, R. Alaggio, M. S. Benassi, L. Pazzaglia, K. Scotlandi, , H. Peinado

This study identifies endoglin (ENG) as a biomarker and therapeutic target for MPNSTs, showing that targeting ENG with antibodies or combining it with MEK inhibitors reduces tumor growth and metastasis.

Clinical Cancer Research · Jul 11, 2023Peer-reviewedCancer Biology

A drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent local relapse and treat established brain metastasis

L. Zhu, N. Yebra, D. Retana, L. Miarka, E. Hernandez-Encinas, C. Blanco-Aparicio, S. Martinez, R. Soffietti, L. Bertero, P. Cassoni, T. Weiss, J. Munoz, J. M. Sepulveda, A. Perez-Nunez, A. Hernandez-Lain, , M. Valiente

The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.

bioRxiv · Oct 16, 2020 · PreprintCancer Biology

The GATA3 X308_Splice breast cancer mutation is a hormone context-dependent oncogenic driver

N. Hruschka, M. Subijana, O. Grana-Castro, F. Del Cano-Ochoa, L. Pare Brunet, A. Sagrera, A. De Reynies, D. Andreu, J. Sutton, I. Chernukhin, S.-F. Chin, C. Caldas, A. Lluch, O. Burgues, B. Bermejo, , P. Martinelli

The paper investigates the context-dependent oncogenic effects of the GATA3 X308_Splice mutation in breast cancer, showing its differential impact based on hormonal status.

bioRxiv · Jun 8, 2019Cancer Biology

Dynamic interactions of lymphatic vessels at the hair follicle stem cell niche during hair regeneration

D. Pena-Jimenez, S. Fontenete, D. Megias, C. Fustero-Torre, O. Grana-Castro, D. Castellana, R. Loewe, M. Perez-Moreno

This study shows lymphatic vessels interact with hair follicle stem cells during regeneration, expanding in response to HF growth and influencing tissue drainage.

bioRxiv · Feb 13, 2019Cell Biology