F. E.-H. Lee

Natural malaria infection elicits rare but potent neutralizing antibodies to the blood-stage antigen RH5

The paper identifies potent neutralizing antibodies against the malaria antigen RH5 from natural infection, showing they target similar epitopes as vaccine-induced antibodies.

Majority of human circulating plasmablasts stop blasting: A probable misnomer

The study shows most blood plasmablasts are not actively dividing, suggesting the term 'plasmablast' may be misleading.

Human Bone Marrow Plasma Cell Atlas: Maturation and Survival Pathways Unraveled by Single Cell Analyses

The study maps human bone marrow plasma cell heterogeneity using single-cell transcriptomics, revealing maturation pathways and molecular features of long-lived plasma cells.

mRNA bivalent booster enhances neutralization against BA.2.75.2 and BQ.1.1

This study evaluates the neutralizing efficacy of bivalent mRNA boosters against emerging SARS-CoV-2 subvariants BA.2.75.2 and BQ.1.1, showing improved protection compared to monovalent boosters.

Inactivation of SARS Coronavirus 2 and COVID-19 patient samples for contemporary immunology and metabolomics studies

This paper demonstrates optimal viral inactivation methods for SARS-CoV-2 and COVID-19 patient samples to enable safe handling at lower biosafety levels while preserving downstream assay fidelity.

Pathogenic neutrophilia drives acute respiratory distress syndrome in severe COVID-19 patients

The paper identifies pathogenic neutrophilia as a driver of acute respiratory distress syndrome in severe COVID-19 patients, highlighting IL-8/CXCR2-mediated neutrophil recruitment and hyperinflammation.

Maturation of Human Long-lived Plasma Cells Results in Resistance to Apoptosis by Transcriptional and Epigenetic Regulation

This study shows human blood ASCs undergo transcriptional and epigenetic changes in the BM microniche to become apoptotic-resistant LLPC.

Ultrapotent bispecific antibodies neutralize emerging SARS-CoV-2 variants

This study identifies ultrapotent bispecific antibodies that neutralize emerging SARS-CoV-2 variants by targeting multiple spike protein regions, showing efficacy in vitro and in a hamster model.

Elevated SARS-CoV-2 Antibodies Distinguish Severe Disease in Early COVID-19 Infection

This paper develops a multiplex immunoassay to measure SARS-CoV-2 antibody responses and finds that severe COVID-19 is associated with higher early antibody levels against S1 and N proteins.

Rapid isolation and profiling of a diverse panel of human monoclonal antibodies targeting the SARS-CoV-2 spike protein

This study isolates and profiles human monoclonal antibodies against SARS-CoV-2 spike protein, identifying neutralizing antibodies targeting the receptor-binding domain.

Novel Immunoassay for Diagnosis of Ongoing Clostridioides difficile Infections Using Serum and Medium Enriched for Newly Synthesized Antibodies (MENSA)

This study develops a multiplex immunoassay using serum and MENSA to diagnose active CDI, finding that combining both methods improves detection compared to using either alone.