K. Furukawa

Extracellular vesicles adhere to cells primarily by interactions of integrins and GM1 with laminin

The paper shows tumor-derived extracellular vesicles bind to laminin via integrins and GM1, inducing cell responses.

Discovery of anti-SARS-CoV-2 S2 protein antibody CV804 with broad-spectrum reactivity with various beta coronaviruses and analysis of its pharmacological properties in vitro and in vivo

This study identifies an antibody, CV804, that targets the conserved S2 domain of coronaviruses and shows broad cross-reactivity and ADCC activity against SARS-CoV-2 and related viruses.

Ras Activation by Hydrostatic Pressure is Enhanced by GAP and GEF in vitro

This study investigates how hydrostatic pressure activates Ras in vitro and shows that GAP and GEF domains enhance this activation.

The lipid Gb3 promotes germinal center B cell responses and anti-viral immunity

The paper shows that Gb3 lipid on GC B cells enhances antibody affinity and breadth, promoting cross-protective immunity against influenza.

AP2A1 is upregulated upon replicative senescence of human fibroblasts to strengthen focal adhesions via integrin β1 translocation along stress fibers

The paper identifies AP2A1 upregulation in senescent human fibroblasts, which strengthens focal adhesions via integrin β1 translocation along stress fibers, maintaining large cell size.

A stress sensor IRE1α is required for bacterial exotoxin-induced inflammasome activation in tissue-resident macrophages

The paper shows that IRE1α is essential for CTB and CT-induced IL-1β production in tissue-resident macrophages via NLRP3 and pyrin inflammasomes.

A model explaining environmental stiffness-dependent migration of fibroblasts with a focus on maturation of intracellular structures

The paper develops a mathematical model to explain how fibroblast migration velocity depends on substrate stiffness through changes in stress fiber maturation and contractile force.

Novel monoclonal antibodies showing broad neutralizing activity for SARS-CoV-2 variants including Omicrons BA.5 and BA.2.75

Nardilysin-Regulated Scission Mechanism Activates Polo-like Kinase 3 to Suppress the Development of Pancreatic Cancer

The paper identifies a post-translational mechanism where Nardilysin cleaves Plk3 to generate an active form that suppresses pancreatic cancer development and metastasis.

Phosphorylation and dephosphorylation of Ser852 and Ser889 control clustering, localization, and function of PAR-3

This study shows that phosphorylation and dephosphorylation of PAR-3 at Ser852 and Ser889 regulate its clustering, localization, and function in cell polarity and junction formation.