S. Deguchi

Mutual interplay of actin meshwork and stress fibers in cellular adaptive response: Insights from percolation dynamics

The paper uses percolation theory to show how actin filaments form stress fibers through stochastic interactions, with assembly influenced by preexisting actin meshwork and disassembly independent of it.

Virological characteristics of the SARS-CoV-2 BA.2.86 variant

This study investigates the virological characteristics of the SARS-CoV-2 BA.2.86 variant, finding it has higher reproduction number than EG.5.1 but lower pathogenicity and replication capacity compared to BA.2.

Virological characteristics of the SARS-CoV-2 Omicron EG.5.1 variant

The paper investigates the virological features of the SARS-CoV-2 EG.5.1 variant, finding its fitness and antiviral sensitivity comparable to XBB.1.5, with structural differences in spike proteins.

AP2A1 is upregulated upon replicative senescence of human fibroblasts to strengthen focal adhesions via integrin β1 translocation along stress fibers

The paper identifies AP2A1 upregulation in senescent human fibroblasts, which strengthens focal adhesions via integrin β1 translocation along stress fibers, maintaining large cell size.

Virological characteristics of the SARS-CoV-2 XBB.1.5 variant

The paper analyzes the virological characteristics of the SARS-CoV-2 XBB.1.5 variant, showing reduced pathogenicity and impaired MHC expression due to mutations in ORF8 and S.

Genetic and functional diversity of beta-N-acetylgalactosamine residue-targeting glycosidases expanded by deep-sea metagenome

This study identifies and characterizes novel beta-N-acetylgalactosaminidases from deep-sea metagenomes, revealing structural diversity and substrate specificity expansion.

A model explaining environmental stiffness-dependent migration of fibroblasts with a focus on maturation of intracellular structures

The paper develops a mathematical model to explain how fibroblast migration velocity depends on substrate stiffness through changes in stress fiber maturation and contractile force.

Virological characteristics of the SARS-CoV-2 XBB variant derived from recombination of two Omicron subvariants

This study identifies XBB as a SARS-CoV-2 variant resulting from recombination of BA.2 subvariants, showing increased resistance to neutralizing antibodies and enhanced fusogenicity compared to BA.2.75.

Convergent evolution of the SARS-CoV-2 Omicron subvariants leading to the emergence of BQ.1.1 variant

The paper investigates convergent evolution in SARS-CoV-2 Omicron subvariants, identifying five critical spike protein substitutions in BQ.1.1 that enhance viral fitness and antibody resistance.

Virological characteristics of the SARS-CoV-2 Omicron BA.2.75

This study investigates the virological characteristics of SARS-CoV-2 Omicron BA.2.75, finding it has higher transmissibility and pathogenicity compared to BA.2 and BA.5, but similar sensitivity to antiviral drugs.

Emergence of multiple set-points of cellular homeostatic tension

The paper investigates how stress fibers in cells can exhibit multiple stable tension levels, explaining the emergence of different homeostatic set-points under varying mechanical conditions.

Analysis of chemical and mechanical behaviors in living cells by continuum mechanics-based FRAP

This study develops a continuum mechanics-based model to analyze long-term FRAP responses, revealing spatially distinct molecular turnover rates and mechanical properties in living cells.

A model for determining the length distribution of actin filaments in cells

The paper develops a theoretical model to determine the length distribution of actin filaments that maintains cellular tensional homeostasis by optimizing entropic quantities under constraints of actin molecules and tension.

Long-term molecular turnover of actin stress fibers revealed by advection-reaction analysis in fluorescence recovery after photobleaching

This study develops a new FRAP model to analyze long-term molecular turnover, revealing that advection and chemical reaction rates are comparable in actin stress fibers.

Proteome of actin stress fibers

The paper identifies the proteome of actin stress fibers in human fibroblasts and shows that eEF2 is upregulated with replicative senescence, contributing to SF reinforcement.

Wrinkle force microscopy: a new machine learning based approach to predict cell mechanics from images

This paper introduces a machine learning method to predict cellular forces from microscope images by training on wrinkle patterns and traction force data.

Determining the domain-level reaction-diffusion properties of cellular proteins by incorporating genetic engineering to FRAP-based framework

This paper introduces a FRAP-based framework with genetic engineering to determine domain-level reaction and diffusion properties of proteins, demonstrating its application to transgelin-2.

Statistical profiling reveals correlations between the cell response to and structural sequence of Rho-GAPs

The paper analyzes the correlation between the morphological response of cells to Rho-GAP silencing and their structural sequence similarity.