Author

N. Tapinos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

A. Fiser· 4 shared D. Karambizi· 3 shared C. Guetta-Terrier· 2 shared E. Fajardo· 2 shared J. E. Fajardo· 2 shared J. P. Zepecki· 2 shared J.-S. Chen· 2 shared S. A. Toms· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersCancer Biology

A. Fiser

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Inhibition of HDAC7 reprograms the histone H3.3 landscape to induce heterochromatin spreading and DNA replication defects in cancer cells.

O. Hassan, M. Pizzagalli, O. Leary, J. P. Zepecki, A. Corseri, L. J. Wu, S. Sasipalli, D. Lee, L. Hayward, L. Tran, E. Fajardo, A. Fiser, D. Karambizi, N. Tapinos

This study shows that inhibiting HDAC7 alters H3.3 deposition and chromatin structure, leading to DNA replication defects and increased sensitivity to DNA damage in cancer cells.

bioRxiv · Mar 12, 2024Cancer Biology

Engineering GliaTrap: a biodegradable non-swelling hydrogel with tuned release of CXCL12 to attract migrating glioblastoma cells

Y. Suita, S. Miriyala, D. Merih-Toruner, W. Yue, L. Xie, B. Akobundu, N. Perch, A. Fiser, E. Fajardo, J. Shen, N. Tapinos

GliaTrap is a biodegradable non-swelling hydrogel with tuned release of a chemoattractant to attract invading glioma cells and serve as delivery platform for local therapeutics.

bioRxiv · Apr 12, 2023 · PreprintCancer Biology

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

C. Noyes, S. Kitajima, F. Li, Y. Suita, S. Miriyala, S. Isaac, N. Ahsan, E. Knelson, A. Vajdi Hoojghan, T. Tani, T. Thai, D. Xu, J. Murai, N. Tapinos, C. Takahashi, , M. Yajima

This study shows DDX4, a germline factor, enhances chemoresistance and motility in SCLC cells by altering metabolism and EMT-like features.

bioRxiv · Apr 22, 2022Cancer Biology

Chi3l1 is a modulator of glioma stem cell states and a therapeutic vulnerability for glioblastoma

C. Guetta-Terrier, D. Karambizi, B. Akosman, J.-S. Chen, S. Kamle, J. E. Fajardo, A. Fiser, R. Singh, S. A. Toms, C. G. Lee, J. A. Elias, N. Tapinos

This study shows Chi3l1 modulates glioma stem cell states by altering transcription factor activity and cell state transitions, and demonstrates anti-Chi3l1 antibody treatment inhibits glioblastoma growth.

bioRxiv · Oct 1, 2021 · PreprintCancer Biology

miRNA-mediated loss of m6A increases nascent translation in glioblastoma

J. P. Zepecki, D. Karambizi, J. E. Fajardo, K. M. Snyder, C. Guetta-Terrier, O. Y. Tang, J.-S. Chen, A. Sarkar, A. Fiser, S. A. Toms, N. Tapinos

The paper shows that miRNA-mediated loss of m6A increases nascent translation in glioblastoma stem cells during differentiation.

bioRxiv · Aug 28, 2020Cancer Biology