Author

T. Tani

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biophysics· 2 Bioengineering· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 6 Approach:experimental assay· 5 Assay:imaging· 4 Approach:microscopy & imaging analysis· 4 Organism:C. elegans· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Assay:fluorescence / live-cell microscopy· 2

Frequent Co-Authors

R. Oldenbourg· 3 shared H. Ishii· 2 shared M. Shribak· 2 shared S. B. Mehta· 2 shared S. Kitajima· 2 shared A. Kimura· 1 shared A. Sugizaki· 1 shared A. Vajdi Hoojghan· 1 shared

Activity by Year

2016-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBiophysics

R. Oldenbourg

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Author profile →

8 papers

Recent·Most cited

Live-cell imaging under centrifugation characterized the cellular force for nuclear centration in the Caenorhabditis elegans embryo

M. Goda, M. Shribak, Z. Ikeda, N. Okada, T. Tani, G. Goshima, R. Oldenbourg, A. Kimura

The paper measures cellular forces for nuclear centration in C. elegans embryos using centrifugation and microscopy, finding forces increase linearly with distance and friction is reduced in microtubule mutants.

bioRxiv · Jan 3, 2024 · PreprintBiophysics

Orientation-Independent-DIC imaging reveals that a transient rise in depletion force contributes to mitotic chromosome condensation

S. Iida, S. Ide, S. Tamura, T. Tani, T. Goto, M. Shribak, K. Maeshima

The paper uses OI-DIC imaging to show that a transient increase in depletion force, caused by macromolecular crowding, contributes to mitotic chromosome condensation in human cells.

bioRxiv · Nov 11, 2023Cell Biology

The germline factor DDX4 contributes to the chemoresistance of small cell lung cancer cells

C. Noyes, S. Kitajima, F. Li, Y. Suita, S. Miriyala, S. Isaac, N. Ahsan, E. Knelson, A. Vajdi Hoojghan, T. Tani, T. Thai, D. Xu, J. Murai, N. Tapinos, C. Takahashi, , M. Yajima

This study shows DDX4, a germline factor, enhances chemoresistance and motility in SCLC cells by altering metabolism and EMT-like features.

bioRxiv · Apr 22, 2022Cancer Biology

POLArIS, a versatile probe for molecular orientation, revealed actin filaments associated with microtubule asters in early embryos

A. Sugizaki, K. Sato, K. Chiba, K. Saito, M. Kawagishi, Y. Tomabechi, S. B. Mehta, H. Ishii, N. Sakai, M. Shirouzu, T. Tani, S. Terada

The paper introduces POLArIS, a probe for molecular orientation imaging, and demonstrates its use in visualizing actin filaments associated with microtubule asters in early embryos.

Proceedings of the National Academy of Sciences · Mar 5, 2021Peer-reviewedCell Biology

Engineering the Immune Adaptor Protein STING as a Biologic

X. Sun, Y. Ni, Y. He, M. Yang, T. Tani, S. Kitajima, D. A. Barbie, J. Li

This study engineers the STING protein as a delivery system to enhance CDN delivery and restore STING signaling in cancer cells.

bioRxiv · Feb 18, 2021 · PreprintBioengineering

Spatial organization of cortical actin alignments for the ooplasmic segregation of ascidian Ciona eggs

T. Tani, H. Ishii

The paper uses fluorescence polarization microscopy to observe cortical actin alignments in Ciona eggs during ooplasmic segregation, showing their role in cytoplasmic reorganization.

bioRxiv · Nov 20, 2019Cell Biology

Instantaneous polarized light imaging reveals activity dependent structural changes of dendrites in mouse hippocampal slices

M. Koike-Tani, T. Tominaga, R. Oldenbourg, T. Tani

The paper uses polarized light imaging to detect activity-dependent structural changes in dendrites of mouse hippocampal slices, revealing birefringence variations linked to synaptic activity.

bioRxiv · Jan 17, 2019 · PreprintBiophysics

Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration

P. Nordenfelt, T. I. Moore, S. B. Mehta, J. M. Kalappurakkal, V. Swaminathan, N. Koga, T. J. Lambert, D. Baker, J. C. Waters, R. Oldenbourg, T. Tani, S. Mayor, C. M. Waterman, T. A. Springer

The paper shows that integrin orientation is dictated by actin flow direction and cytoskeletal forces during leukocyte migration.

bioRxiv · Aug 27, 2016Cell Biology