PRMT5 inhibition induces a histone methylation switch that drives chromatin plasticity, drug resistance, and metastatic progression
Colin E Fowler, Natalie A. O’Hearn, Nicole Henning…·Jacqueline A. Lees
This study shows PRMT5 inhibition causes splicing defects and epigenetic changes leading to drug resistance and metastatic progression in lung adenocarcinoma.