Nathalie Escalas

Cell-to-cell heterogeneity in Sox2 and Brachyury expression ratios guides progenitor destiny by controlling their motility.

The paper shows that variations in Sox2-to-Bra protein ratios in posterior progenitors influence their motility and fate, guiding their contribution to neural or mesodermal tissues.

Neuroepithelial progenitors generate and propagate non-neuronal action potentials across the spinal cord

The paper shows spinal neuroepithelial progenitors generate and propagate action potentials independently of neurons during spontaneous neural activity.

Transcriptome profiling of the Olig2-expressing astrocyte subtype reveals their unique molecular signature

The paper identifies a unique molecular signature of Olig2-expressing astrocytes through transcriptome profiling and differential gene expression analysis.

Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord

This study shows that Sulf2a regulates Shh-dependent neural fate specification in zebrafish spinal cord development by modulating Shh signaling and cell type differentiation.

Identification of a Sulf2-dependant astrocyte subtype that stands out through the expression of Olig2 in the ventral spinal cord

The paper identifies an Olig2-expressing astrocyte precursor subtype in the ventral spinal cord that depends on Sulf2 for its generation.

FGFs are orchestra conductors of Shh-dependent oligodendroglial fate specification in the ventral spinal cord

The paper shows FGF signaling is required for ventral oligodendrocyte precursor cell generation alongside Shh, with FGFs also regulating Shh signaling and Olig2 expression.

Eph/ephrin signaling controls progenitor identities in the ventral spinal cord

This study shows Eph:ephrin signaling maintains progenitor identities in the ventral spinal cord by regulating transcription factor expression.