Jeroen Kneppers

Agent-based modeling of the prostate tumor microenvironment uncovers spatial tumor growth constraints and immunomodulatory properties

This study uses an agent-based model to simulate prostate cancer growth and ADT effects, revealing CRPC development and immunomodulatory interactions in the tumor microenvironment.

Exploring the onset and progression of prostate cancer through a multicellular agent-based model

This study develops an agent-based model of prostate cancer progression, showing that stochastic interactions and systematic factors influence tumor development and clinical outcomes.

DNA-guided DNA cleavage at moderate temperatures by Clostridium butyricum Argonaute

This study characterizes CbAgo, a mesophilic prokaryotic Argonaute that enables DNA-guided DNA cleavage at moderate temperatures using specific siDNA guides.

Multiplex gene editing by CRISPR-Cpf1 through autonomous processing of a single crRNA array

The paper demonstrates multiplex gene editing in mammalian cells and mouse brains using a single CRISPR array processed by Cpf1 without requiring additional factors.