A unified photosensitizer platform for in situ DNA, RNA, and protein directed proximity labeling
Elijah Biletch, Conor P. Herlihy, Lidan Li, Mary Krebs, Conor J Kelly, Nicolas J. Longhi, Olivia Weissenfels, Hanna G. Goldberg, Kyle Brandt, Jonathan B. Grimm, Luke D. Lavis, Edward L. Huttlin, Devin K. Schweppe, Keriann M. Backus, Brian J. Beliveau
The paper introduces POCA, a photosensitizer platform for proximity labeling of proteins, RNA, and DNA in fixed cells without genetic engineering, demonstrating its utility across multiple molecular targets.
bioRxiv · May 1, 2026 · PreprintCell Biology