Entorhinal Cortex Wolframin-1-expressing neurons propagate tau to CA1 neurons and impair hippocampal memory
Jean-Christophe Delpech, Srinidhi Venkatesan Kalavai, Dhruba Pathak, Arun Reddy Ravula, Heena Vanmalibhai Lad, Emma Catherine Hays, Nina Touch, Andrea Rau, Charlotte Madore, Maria Medalla, Jennifer Irene Luebke, Seiko Ikezu, Tsuneya Ikezu
This study shows that tau propagation from entorhinal cortex to hippocampal CA1 neurons leads to sex-specific cognitive and electrophysiological impairments, driven by distinct neuroimmune responses in males and females.
bioRxiv · Feb 20, 2026 · PreprintNeuroscience