L. Kong

CTFFIND5 provides improved insight into quality, tilt and thickness of TEM samples

CTFFIND5 improves CTF estimation by incorporating sample thickness and tilt, enhancing cryoEM image quality assessment.

The Alexander Disease Protein GFAP Drives Mitochondrial Fission

This study identifies GFAP as a novel mediator of mitochondrial fission by surrounding fission sites and modulating Drp1 recruitment, revealing a new mechanism in mitochondrial plasticity.

Modulation of stress granule dynamics by phosphorylation and ubiquitination in plants

This study identifies phosphorylation and ubiquitination as key regulators of TZF1 stress granule assembly in Arabidopsis.

3D Bioprinting of Human Neural Tissues with Functional Connectivity

This study develops a 3D bioprinting platform to create human neural tissues with functional connectivity, showing differentiation into neurons and astrocytes and forming functional circuits.

Beige adipose tissue-derived extracellular vesicles: a potent metabolic regulator and a novel remedy for nonalcoholic fatty liver disease

This study isolates and characterizes beige adipose tissue-derived extracellular vesicles (BeEVs) and shows they improve metabolic dysfunction in a nonalcoholic fatty liver disease model.

Alternative splicing of a potato disease resistance gene maintains homeostasis between development and immunity

The paper shows that the potato resistance gene RB uses alternative splicing to balance growth and immunity, with the pathogen effector IPI-O1 promoting splicing to enhance immunity.

Neo-functionalization and co-option of Pif genes facilitate the evolution of a novel shell microstructure in oysters

This study identifies neo-functionalization and co-option of Pif genes in oysters that contribute to the evolution of a novel shell microstructure called chalky calcite.

A special satellite-like dsRNA of a novel hypovirus from Pestalotiopsis fici broadens the definition of satellite

The paper identifies and characterizes a novel hypovirus and its satellite-like dsRNA from Pestalotiopsis fici, showing it lacks a poly(A) tail and ORF, and negatively regulates the helper virus.

Novel Viroid-like RNAs Naturally Infect a Filamentous Fungus

The paper identifies novel viroid-like circular RNAs in a fungal host, showing they replicate autonomously and modulate host biology, suggesting a new class of viroid-like entities in fungi.

AI inspired discovery of new biomarkers for clinical prognosis of liver cancer

This paper introduces PathFinder, an interpretable AI framework for discovering new tissue biomarkers in liver cancer, identifying tumor necrosis as a prognostic factor.

High axial-resolution optical stimulation of neurons in vivo via two-photon optogenetics with speckle-free beaded-ring pattern

This paper introduces a beaded-ring pattern for two-photon optogenetics to improve axial resolution in vivo, showing a 24% improvement over disk patterns when stimulating multiple neurons.

Interferon regulatory factor 3 upregulates the Treg recruitment factor CCL22 in response to double-stranded DNA in cancer cells

This study identifies IRF3 as a key regulator of CCL22 expression in cancer cells in response to dsDNA, linking STING activation to immunosuppressive mechanisms.

Intergenerational transfer and sex differences of DNA methylation patterns in the Pacific oyster (Crassostrea gigas)

This study investigates DNA methylation inheritance in Pacific oysters, finding that half of parental methylation differences are passed to offspring and revealing sex-specific methylation patterns linked to Rho signaling.

Voxelated Bioprinting of Mechanically Robust Multiscale Porous Scaffolds for Pancreatic Islets

This paper introduces a 3D bioprinting technique called DASP to create mechanically robust, multiscale porous scaffolds for encapsulating human pancreatic islets to enable responsive insulin release.

Urocortin 3 in the posterodorsal medial amygdala mediates psychosocial stress-induced suppression of LH pulsatility in female mice

This study shows that Urocortin3 in the MePD mediates psychosocial stress-induced suppression of LH pulsatility and CORT release in female mice.

Glycerol monolaurate ameliorated intestinal barrier and immunity in broilers by regulating intestinal inflammation, antioxidant balance, and intestinal microbiota

This study shows that Glycerol monolaurate improves intestinal barrier and immunity in broilers by reducing inflammation, enhancing antioxidant balance, and modulating gut microbiota.

Protein phosphatase 1 regulatory inhibitor subunit 14C promotes triple-negative breast cancer progression via sustaining inactive glycogen synthase kinase 3 beta

This study identifies PPP1R14C as a driver of triple-negative breast cancer progression by inactivating GSK3β through PP1 inhibition and TRIM25-mediated degradation of non-phosphorylated GSK3β.

MAPK Pathway Inhibition as A Rational Therapeutic Strategy for MiR-138-5p/PAQR3 Dysregulation-mediated Epirubicin Resistance in Triple-negative Breast Cancer

This study identifies PAQR3 as a predictor of epirubicin response in TNBC and shows that MAPK inhibition can reverse resistance caused by miR-138-5p-mediated PAQR3 downregulation.

Elongation Inhibitors do not Prevent the Release of Puromycylated Nascent Polypeptide Chains from Ribosomes

This study shows that elongation inhibitors do not prevent the release of puromycylated nascent polypeptides from ribosomes, challenging the use of anti-puromycin staining to determine translation sites.

Three-dimensional Genome Organization Maps in Normal Haematopoietic Stem Cells and Acute Myeloid Leukemia

This study maps 3D genome organization in normal and AML haematopoietic stem cells, finding increased chromatin loops to oncogenes in AML and identifying MEIS1 and HOXA9 as key oncogenes regulated by these interactions.

Potential function of CbuSPL and gene encoding its interacting protein during flowering in Catalpa bungei

The paper identifies CbuSPL9 and its interacting protein CbuHMGA in Catalpa bungei, showing they form a heterodimer and may regulate flowering development, not transition.

Source-Sink Modifications Affect Leaf Senescence and Grain Mass in Wheat

This study manipulates sink/source ratios in wheat to show effects on leaf senescence and grain mass through hormonal changes, enzyme activities, and metabolic shifts.

Restoring p53 Function and Silencing REV3L Suppresses the Cancerous Metabolic Phenotype in Cisplatin Treated Human Non-Small Lung Carcinoma Cells

This study shows that restoring p53 and silencing REV3L reduces cancerous metabolic traits and increases cell death in cisplatin-treated lung cancer cells.