O. Billker

Extracellular ATP is an environmental cue in bacteria

This study shows that extracellular ATP (eATP) acts as an environmental cue for bacteria, altering their transcription, metabolism, and virulence.

Reverse genetic screen identifies malaria parasite genes required for gametocyte-to-sporozoite development in its mosquito host

This study uses a reverse genetic screen in Plasmodium berghei to identify genes essential for gametocyte-to-sporozoite development in the mosquito Anopheles coluzzii, confirming prior findings and discovering new genes involved in key stages of the parasite lifecycle.

A non-canonical sensing pathway mediates Plasmodium adaptation to AA deficiency

This study identifies a non-canonical AA-sensing pathway in Plasmodium that enables adaptation to amino acid deficiency through kinases eIK1 and eIK2.

GDV1 C-terminal truncation of 39 amino acids disrupts sexual commitment in Plasmodium falciparum

This study identifies a C-terminal truncation mutation in GDV1 that disrupts sexual commitment in Plasmodium falciparum by destabilizing the protein, despite normal nuclear import and HP1 interaction.

Signalome-wide assessment of erythrocyte response to Plasmodium reveals novel targets for host-directed antimalarial intervention

The paper assesses host erythrocyte signaling during Plasmodium infection and identifies c-MET and B-Raf as potential targets for antimalarial intervention.

Mosquito cellular immunity at single-cell resolution

The paper profiles hemocytes from two mosquito species to reveal functional diversity and identifies a new cell type, providing an atlas of mosquito immune cells at single-cell resolution.

Sub-minute phosphoregulation of cell-cycle systems during Plasmodium gamete formation

This study identifies phosphoregulation networks during Plasmodium gamete formation using high-resolution phosphoproteomics.