P. Beltrao

Multi-tissue proteomics identifies a link between satellite DNA organization and heritable transposon repression in Drosophila

Meiotic Nuclear Pore Complex Remodeling Provides Key Insights into Nuclear Basket Organization

The paper identifies two distinct nuclear pore complex remodeling events during budding yeast meiosis, revealing conserved mechanisms of nuclear basket organization.

A structural biology community assessment of AlphaFold 2 applications

This study assesses AlphaFold 2's applications in structural biology, finding it outperforms existing tools in predicting disorder, complexes, and structural features with high confidence.

Clinical and molecular features of acquired resistance to immunotherapy in non-small cell lung cancer

This study characterizes clinical and molecular features of acquired resistance to PD-(L)1 blockade in NSCLC, identifying persistent inflammation and dysfunctional IFN signaling as key features.

Pan-Cancer landscape of protein activities identifies drivers of signalling dysregulation and patient survival

The paper analyzes protein activity changes in cancer using genomics and proteomics data to identify drivers of signaling dysregulation and their impact on patient survival.

Evolution of enhanced innate immune evasion by the SARS-CoV-2 B.1.1.7 UK variant

This study identifies that the B.1.1.7 SARS-CoV-2 variant enhances innate immune evasion through increased Orf9b and Orf6 expression and activity.

Major role of iron uptake systems in the intrinsic extra-intestinal virulence of the genus Escherichia revealed by a genome-wide association study

This study identifies iron uptake systems, particularly the high-pathogenicity island, as key drivers of extra-intestinal virulence in Escherichia through a genome-wide association analysis in a mouse sepsis model.

Global post-translational modification profiling of HIV-1-infected cells reveals mechanisms of host cellular pathway remodeling

The paper uses proteomics to analyze PTM changes in HIV-1-infected cells, identifying mechanisms of host pathway remodeling through Aurora kinase A and PP2A modulation.

Evolution of protein kinase substrate recognition at the active site

The paper investigates the evolution of kinase substrate recognition, showing early sequence variation in specificity residues and stability of specificity in recent duplications, with phosphorylation motifs broadly distributed in eukaryotes.

Global analysis of specificity determinants in eukaryotic protein kinases

The paper identifies 30 putative specificity determinant residues in protein kinases and shows their conservation and mutation patterns in cancer and evolution.

Conserved phosphorylation hotspots in eukaryotic protein domain families

The paper identifies conserved phosphorylation hotspots across 40 eukaryotic species and shows their functional importance in protein domains.

Sub-minute phosphoregulation of cell-cycle systems during Plasmodium gamete formation

This study identifies phosphoregulation networks during Plasmodium gamete formation using high-resolution phosphoproteomics.