Author

O. Kovtun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Assay:imaging· 3 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1 Organism:human· 1

Frequent Co-Authors

A. Crabtree· 2 shared A. G. Marshall· 2 shared A. Kinder· 2 shared A. Kirabo· 2 shared A. Quintana· 2 shared B. M. Collins· 2 shared C. Dash· 2 shared C. Evans· 2 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersPhysiology

A. Crabtree

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

S. K. Masenga, A. C. Murphy, P. Venkhatesh, Z. Vue, A. A. Kadam, A. G. Marshall, B. I. Rodriguez, E. Scudese, B. C. Jenkins, A. Crabtree, P. Prasad, E. G. Lopez, H. Le, K. Actkins, E. Zaganjor, , C. P. H Perez

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

bioRxiv · Jun 20, 2024 · PreprintPhysiology

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

P. Katti, P. Prasad, S. K. Masenga, P. Venkhatesh, Z. Vue, A. G. Marshall, B. Rodrageaz, H. Le, E. Garza-Lopez, A. Murphy, B. Jenkins, A. Kadam, J. Shao, A. Crabtree, P. Martin, , McReyn

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

bioRxiv · Jun 9, 2024Physiology

Molecular basis for the assembly of the Vps5-Vps17 SNX-BAR proteins with Retromer

K.-E. Chen, V. A. Tillu, N. Gopaldass, S. R. Chowdhury, N. Leneva, O. Kovtun, J. Ruan, Q. Guo, N. Ariotti, A. Mayer, B. M. Collins

This study investigates how Vps5 and Vps17 SNX-BAR proteins assemble with Retromer, revealing a PL motif in Vps5 that binds Vps29 and is essential for membrane tubule association and cargo recycling.

bioRxiv · Mar 24, 2024Cell Biology

FCHO controls AP2's critical endocytic roles through a PtdIns4,5P2 membrane-dependent switch

N. R. Zaccai, Z. Kadlecova, V. Kane Dickson, K. Korobchevskaya, J. Kamenicky, O. Kovtun, P. K. Umasankar, A. G. Wrobel, J. G. G. Kaufman, S. R. Gray, K. Qu, P. R. Evans, M. Fritzsche, F. Sroubek, S. Höning, , L. M. Traub

The paper shows FCHO primes AP2 for clathrin-coated vesicle incorporation, triggering FCHO release to enable further AP2 activation and recruitment.

bioRxiv · Apr 2, 2022 · PreprintCell Biology

Cavin1 intrinsically disordered domains are essential for fuzzy electrostatic interactions and caveola formation

V. Tillu, J. Rae, Y. Gao, N. Ariotti, M. Floetenmeyer, O. Kovtun, K.-A. McMahon, N. Chaudhary, R. G. Parton, B. M. Collins

This study shows that Cavin1's intrinsically disordered domains are essential for caveola formation and trafficking through electrostatic interactions and phase separation.

bioRxiv · Sep 16, 2020Cell Biology