O. Namy

The Ribosome Profiling landscape of yeast reveals a high diversity in pervasive translation

The paper analyzes Ribosome Profiling data in yeast to show noncoding regions exhibit diverse translation signals, including non-canonical ones, and that translation of noncoding ORFs is determined by start codon and codon distribution.

Aminoglycoside tolerance in Vibrio cholerae engages translational reprogramming associated with queuosine tRNA modification

This study shows that Q34 modification in tRNA affects translational efficiency in Vibrio cholerae under aminoglycoside stress, leading to reprogramming of gene expression and antibiotic tolerance.

Extensive uORF translation from HIV-1 transcripts conditions DDX3 dependency for expression of main ORFs and elicits specific T cell immune responses in infected individuals

The paper characterizes HIV-1 translational landscape, revealing uORF translation and its role in DDX3 dependency and T cell immune responses.

Translational accuracy of a tethered ribosome

This study examines the translational properties of a tethered ribosome (Ribo-T) in Escherichia coli, showing that covalent subunit linkage affects translation initiation and termination.

Intergenic ORFs as elementary structural modules of de novo gene birth and protein evolution

This study explores how noncoding sequences in yeast can generate structural protein diversity and contribute to de novo gene birth.

The high turnover of ribosome-associated transcripts from de novo ORFs produces gene-like characteristics available for de novo gene emergence in wild yeast populations

The paper examines de novo ORF emergence in wild yeast, finding some intergenic ORFs show gene-like characteristics despite lower translation efficiency and suggesting functional innovation potential.