Author

O. Otun

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1

Frequent Co-Authors

C. BECHARA· 2 shared C. Leyrat· 2 shared S. Granier· 2 shared T. Durroux· 2 shared X. Cong· 2 shared B. Kellam· 1 shared B. Zarzycka· 1 shared C. Aljamous· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

C. BECHARA

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Conformational dynamics underlying Atypical Chemokine Receptor 3 activation

O. Otun, C. Aljamous, E. Del Nero, M. Arimont-Segura, R. Bosma, B. Zarzycka, T. Girbau, C. Leyrat, C. de Graaf, R. Leurs, T. Durroux, S. Granier, X. Cong, C. BECHARA

This study investigates the conformational dynamics of ACKR3 activation using HDX-MS and molecular dynamics simulations, revealing key structural changes and ligand binding mechanisms.

bioRxiv · Jul 17, 2023 · PreprintBiochemistry

Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

C. Leyrat, S. Granier, T. Durroux, C. Bechara, S. Jeannot, F. Peysson, C. M. Grison, P. Verdie, L. Brunel, F. Hoh, X. Cong, O. Otun, P. Lambey

This study investigates how Staphylococcus aureus leukotoxins recognize chemokine receptors, identifying sulfotyrosine binding sites and proposing structural models for receptor-toxin interactions.

bioRxiv · Aug 5, 2021Biochemistry

Ligand-directed covalent labelling of a GPCR with a fluorescent tag

L. A. Stoddart, N. D. Kindon, O. Otun, C. R. Harwood, F. Patera, D. B. Veprintsev, J. Woolard, S. J. Briddon, H. A. Franks, S. J. Hill, B. Kellam

The paper describes a compound that covalently labels a GPCR with a fluorescent tag without blocking its binding site, enabling study of native GPCR function and localization.

bioRxiv · Apr 21, 2020Pharmacology & Toxicology