Author

T. Durroux

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

C. BECHARA· 3 shared C. Leyrat· 3 shared S. Granier· 3 shared C. M. Grison· 2 shared E. Del Nero· 2 shared F. Peysson· 2 shared I. Alves· 2 shared J. Heuninck· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersBiochemistry

C. BECHARA

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Membrane lipid poly-unsaturation selectively affects dopamine D2 receptor internalization

S. Sposini, R. Baccouch, M. Lescuyer, A. A. Mali, V. De Smedt-Peyrusse, J. Heuninck, A. Gorse, T. Durroux, P. Trifilieff, D. Perrais, I. Alves

This study shows that membrane poly-unsaturated fatty acids (PUFAs) impair dopamine D2 receptor (D2R) endocytosis without affecting other GPCRs or clathrin-mediated endocytosis.

bioRxiv · Dec 14, 2023 · PreprintCell Biology

Conformational dynamics underlying Atypical Chemokine Receptor 3 activation

O. Otun, C. Aljamous, E. Del Nero, M. Arimont-Segura, R. Bosma, B. Zarzycka, T. Girbau, C. Leyrat, C. de Graaf, R. Leurs, T. Durroux, S. Granier, X. Cong, C. BECHARA

This study investigates the conformational dynamics of ACKR3 activation using HDX-MS and molecular dynamics simulations, revealing key structural changes and ligand binding mechanisms.

bioRxiv · Jul 17, 2023 · PreprintBiochemistry

Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling

M.-L. Jobin, V. De Smedt-Peyrusse, F. Ducrocq, A. Oummadi, R. Baccouch, M. Hauge Pedersen, B. Medel Lacruz, P. Van-Delft, L. Fouillen, S. Mongrand, J. Selent, T. Tolentino-Cortez, G. Barreda-Gomez, S. Gregoire, E. Masson, , P. Trifilieff

This study shows that n-3 PUFAs enhance D2R ligand binding and signaling, suggesting they act as allosteric modulators of the receptor.

bioRxiv · Jan 4, 2022Cell Biology

Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

C. Leyrat, S. Granier, T. Durroux, C. Bechara, S. Jeannot, F. Peysson, C. M. Grison, P. Verdie, L. Brunel, F. Hoh, X. Cong, O. Otun, P. Lambey

This study investigates how Staphylococcus aureus leukotoxins recognize chemokine receptors, identifying sulfotyrosine binding sites and proposing structural models for receptor-toxin interactions.

bioRxiv · Aug 5, 2021Biochemistry

Mechanisms of GPCR hijacking by Staphylococcus aureus

C. M. Grison, C. Leyrat, P. Lambey, S. Jeannot, E. Del Nero, S. Fontanel, F. Peysson, J. Heuninck, R. Sounier, T. Durroux, S. Granier, C. Bechara

This study investigates how Staphylococcus aureus leukotoxins HlgA and HlgB interact with ACKR1, altering its structure and function to aid bacterial growth and immune evasion.

bioRxiv · Feb 8, 2021 · PreprintBiochemistry