Author

A. H. Hasty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:mouse· 5 Research Focus:metabolism & bioenergetics· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Assay:scRNA-seq· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

M. A. Cottam· 3 shared N. C. Winn· 3 shared H. L. Caslin· 2 shared J. N. Garcia· 2 shared A. Christofides· 1 shared B. I. Reinfeld· 1 shared D. H. Wasserman· 1 shared E. M. Wolf· 1 shared

Activity by Year

2021-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersImmunology

M. A. Cottam

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Insulin at the Intersection of Thermoregulation and Glucose Homeostasis

N. C. Winn, M. W. Schleh, J. N. Garcia, L. Lantier, O. P. McGuinness, J. A. Blair, A. H. Hasty, D. H. Wasserman

This study shows that thermoneutral temperature reduces energy expenditure and insulin-mediated glucose fluxes in mice, while insulin-independent glucose uptake in brown fat adjusts to temperature changes without compromising glucose homeostasis.

bioRxiv · Nov 17, 2023Physiology

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

J. E. Bader, M. M. Wolf, M. Z. Madden, B. I. Reinfeld, E. N. Arner, E. S. Hathaway, K. K. Steiner, G. A. Needle, M. D. Landis, M. A. Cottam, X. Ye, A. Christofides, V. A. Boussiotis, S. M. Haake, K. E. Beckermann, , J. C. Rathmell

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

bioRxiv · Nov 12, 2022 · PreprintImmunology

Weight cycling induces innate immune memory in adipose tissue macrophages

H. L. Caslin, M. A. Cottam, J. M. Pinon, L. Y. Boney, A. H. Hasty

The paper shows weight cycling primes adipose macrophages for enhanced inflammation, worsening glucose tolerance after weight regain.

bioRxiv · Jul 2, 2022 · PreprintImmunology

Trem2 deficiency does not worsen metabolic function in diet-induced obese mice

N. C. Winn, E. M. Wolf, J. N. Garcia, A. H. Hasty

This study shows that Trem2 deficiency does not impair metabolic function in diet-induced obese mice, despite causing adipose tissue changes.

bioRxiv · Jun 13, 2022 · PreprintPhysiology

Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and subsequent weight regain.

M. A. Cottam, H. L. Caslin, N. C. Winn, A. H. Hasty

This study uses multi-omics to show that obesity-related immune cell changes in adipose tissue persist during weight loss and weight regain in mice.

bioRxiv · Aug 20, 2021 · PreprintImmunology