Author

O. Ponomarova

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Organism:C. elegans· 2 Research Focus:development & morphogenesis· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A. Amzallag· 1 shared A. Belfi· 1 shared A. Friedman· 1 shared A. J. M. Walhout· 1 shared A. J. Walhout· 1 shared A. N. Starbard· 1 shared A. Sahu· 1 shared A. V. Anderson· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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1 shared paperCancer Biology

A. Amzallag

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Author profile →

3 papers

Recent·Most cited

idh-1 neomorphic mutation confers sensitivity to vitamin B12 via increased dependency on one-carbon metabolism in Caenorhabditis elegans

O. Ponomarova, A. N. Starbard, A. Belfi, A. V. Anderson, M. V. Sundaram, A. J. Walhout

This study shows that the idh-1neo mutation in C. elegans increases dependency on one-carbon metabolism, making the worms vulnerable to vitamin B12 deficiency and leading to embryonic lethality.

bioRxiv · Mar 13, 2024 · PreprintBiochemistry

A D-2-Hydroxyglutarate dehydrogenase mutant reveals a critical role for ketone body metabolism in Caenorhabditis elegans development

O. Ponomarova, H. Zhang, X. Li, S. Nanda, T. B. Leland, B. W. Fox, G. E. Giese, F. C. Schroeder, S. L. Yilmaz, A. J. M. Walhout

This study shows that in C. elegans, D-2HG is produced via the propionate shunt and that loss of dhgd-1 causes embryonic lethality by disrupting ketone body metabolism, which can be rescued by vitamin B12 or 3-hydroxybutyrate.

bioRxiv · May 16, 2022Biochemistry

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

A. Sahu, J. Sang Lee, G. Zhang, Z. Wang, T. Tian, T. Moll, G. Kasumova, B. Miao, Z. Wei, N. U. Nair, O. Ponomarova, A. Friedman, A. Amzallag, P. Greninger, R. Egan, , E. Ruppin

The paper predicts synthetic rescue mediators of resistance to targeted and immunotherapy using tumor transcriptomics and survival data from 10,000 TCGA patients, validating predictions through experimental screens.

bioRxiv · Apr 8, 2018Cancer Biology